Update on <scp>N6</scp>‐methyladenosine methylation in obesity‐related diseases

Cheng, Caiqin; Yu, Fan; Yuan, Guoyue; Jia, Jue

doi:10.1002/oby.23932

Cited by 4 publications

(5 citation statements)

References 103 publications

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“…RNA m6A modifications have unique functions in regulating hepatic processes and diseases, including lipid metabolism and non-alcoholic fatty liver disease [ 53 , 54 ]. Lipid metabolism primarily occurs in the liver, which is responsible for lipoprotein synthesis, absorption, and transport.…”

Section: Discussionmentioning

confidence: 99%

Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice

Shen,

Chen,

Zhang

et al. 2024

Genes

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Lipid metabolism participates in various physiological processes and has been shown to be connected to the development and progression of multiple diseases, especially metabolic hepatopathy. Apolipoproteins (Apos) act as vectors that combine with lipids, such as cholesterol and triglycerides (TGs). Despite being involved in lipid transportation and metabolism, the critical role of Apos in the maintenance of lipid metabolism has still not been fully revealed. This study sought to clarify variations related to m6A methylome in ApoF gene knockout mice with disordered lipid metabolism based on the bioinformatics method of transcriptome-wide m6A methylome epitranscriptomics. High-throughput methylated RNA immunoprecipitation sequencing (MeRIP-seq) was conducted in both wild-type (WT) and ApoF knockout (KO) mice. As a result, the liver histopathology presented vacuolization and steatosis, and the serum biochemical assays reported abnormal lipid content in KO mice. The m6A-modified mRNAs were conformed consensus sequenced in eukaryotes, and the distribution was enriched within the coding sequences and 3′ non-coding regions. In KO mice, the functional annotation terms of the differentially expressed genes (DEGs) included cholesterol, steroid and lipid metabolism, and lipid storage. In the differentially m6A-methylated mRNAs, the functional annotation terms included cholesterol, TG, and long-chain fatty acid metabolic processes; lipid transport; and liver development. The overlapping DEGs and differential m6A-modified mRNAs were also enriched in terms of lipid metabolism disorder. In conclusion, transcriptome-wide MeRIP sequencing in ApoF KO mice demonstrated the role of this crucial apolipoprotein in liver health and lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice

Shen,

Chen,

Zhang

et al. 2024

Genes

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“…Therefore, further research and development of novel therapeutic tactics are required [13]. In addition, obesity is a chronic metabolic disease that is closely related to type 2 diabetes mellitus, cardiovascular diseases, and osteoarthritis [14]. The prevalence of obesity is increasing rapidly, which is considered to be a global public health burden [14].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, obesity is a chronic metabolic disease that is closely related to type 2 diabetes mellitus, cardiovascular diseases, and osteoarthritis [14]. The prevalence of obesity is increasing rapidly, which is considered to be a global public health burden [14]. However, the precise mechanism and role of m6A-modified ncRNAs in MAFLD are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

Nakashima,

Suga,

Ikeda

et al. 2024

ncRNA

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Noncoding RNAs (ncRNAs), including circular RNAs (circRNAs) and N6-methyladenosine (m6A), have been shown to play a critical role in the development of various diseases including obesity and metabolic disorder-associated fatty liver disease (MAFLD). Obesity is a chronic disease caused by excessive fat accumulation in the body, which has recently become more prevalent and is the foremost risk factor for MAFLD. Causes of obesity may involve the interaction of genetic, behavioral, and social factors. m6A RNA methylation might add a novel inspiration for understanding the development of obesity and MAFLD with post-transcriptional regulation of gene expression. In particular, circRNAs, microRNAs (miRNAs), and m6A might be implicated in the progression of MAFLD. Interestingly, m6A modification can modulate the translation, degradation, and other functions of ncRNAs. miRNAs/circRNAs can also modulate m6A modifications by affecting writers, erasers, and readers. In turn, ncRNAs could modulate the expression of m6A regulators in different ways. However, there is limited evidence on how these ncRNAs and m6A interact to affect the promotion of liver diseases. It seems that m6A can occur in DNA, RNA, and proteins that may be associated with several biological properties. This study provides a mechanistic understanding of the association of m6A modification and ncRNAs with liver diseases, especially for MAFLD. Comprehension of the association between m6A modification and ncRNAs may contribute to the development of treatment tactics for MAFLD.

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“…N6-methyladenosine (M6A), a form of methylation occurring at the sixth N atom of the adenine base (A) of an RNA molecule, is currently considered to be the most abundant and conserved internal RNA modification. RNA M6A modification plays an essential role in RNA splicing, stability, output, degradation, and other metabolic processes [ 2 ], which affects almost all biological processes, such as cell autophagy [ 3 ], cell differentiation [ 4 ], inflammatory response [ 5 ], immune response [ 6 ], metabolic disease [ 7 ], carcinogenesis [ 8 ], and cancer prognosis [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy

Wang,

Yao,

Zhang

et al. 2024

IJMS

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The N6-methyladenosine (M6A) modification is the most common internal chemical modification of RNA molecules in eukaryotes. This modification can affect mRNA metabolism, regulate RNA transcription, nuclear export, splicing, degradation, and translation, and significantly impact various aspects of physiology and pathobiology. Radiotherapy is the most common method of tumor treatment. Different intrinsic cellular mechanisms affect the response of cells to ionizing radiation (IR) and the effectiveness of cancer radiotherapy. In this review, we summarize and discuss recent advances in understanding the roles and mechanisms of RNA M6A methylation in cellular responses to radiation-induced DNA damage and in determining the outcomes of cancer radiotherapy. Insights into RNA M6A methylation in radiation biology may facilitate the improvement of therapeutic strategies for cancer radiotherapy and radioprotection of normal tissues.

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Update on N6‐methyladenosine methylation in obesity‐related diseases

Cited by 4 publications

References 103 publications

Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice

Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice

Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy

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