Update on <scp>K</scp>awasaki disease: Epidemiology, aetiology and pathogenesis

Yim, Deane; Curtis, Nigel; Cheung, Michael; Burgner, David

doi:10.1111/jpc.12172

Cited by 67 publications

(53 citation statements)

References 65 publications

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“…In comparison to the microbiome, the so-called virome [a collection of viruses within an individual, including viruses causing acute infection, such as influenza virus, as well as those associated with persistent or latent infection, such as cytomegalovirus (CMV)] and its impact on human health are relatively understudied and are in the early phases of characterization (1 ). One example of an area of great excitement is large, unbiased surveys that attempt to define a viral etiology for diseases that have been postulated to be attributed to a virus but for which no specific virus has been implicated, such as multiple sclerosis, certain malignancies, or Kawasaki disease (2,3 ).…”

mentioning

confidence: 99%

Your Viral Past: A Comprehensive Method for Serological Profiling to Explore the Human Virome

McAdam

2016

Clinical Chemistry

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mentioning

confidence: 99%

Your Viral Past: A Comprehensive Method for Serological Profiling to Explore the Human Virome

McAdam

2016

Clinical Chemistry

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“…Children outside that range might be diagnosed late in the course of the disease process because they lacked the classic clinical presentation [8,9,11].…”

Section: Kawasaki Diseasementioning

confidence: 98%

“…1) according to vessel size involvement classification criteria devised by EULAR and PReS in 2006, which were based on the criteria from the 1993 Chapel Hill Consensus Conference [3,[8][9][10]. Imaging features of vasculitis per system (central nervous, head and neck, chest, abdominal and musculoskeletal systems), along with differential diagnoses and an algorithm for diagnosis based on common findings will be provided.…”

Section: Introductionmentioning

confidence: 99%

Imaging of systemic vasculitis in childhood

et al. 2015

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The term "systemic vasculitis" encompasses a diverse set of diseases linked by the presence of blood-vessel inflammation that are often associated with critical complications. These diseases are uncommon in childhood and are frequently subjected to a delayed diagnosis. Although the diagnosis and treatment may be similar for adult and childhood systemic vasculitides, the prevalence and classification vary according to the age group under investigation. For example, Kawasaki disease affects children while it is rarely encountered in adults. In 2006, the European League Against Rheumatism (EULAR) and the Pediatric Rheumatology European Society (PReS) proposed a classification system for childhood vasculitis adopting the system devised in the Chapel Hill Consensus Conference in 1993, which categorizes vasculitides according to the predominant size of the involved blood vessels into small, medium and large vessel diseases. Currently, medical imaging has a pivotal role in the diagnosis of vasculitis given recent developments in the imaging of blood vessels. For example, early diagnosis of coronary artery aneurysms, a serious complication of Kawasaki disease, is now possible by magnetic resonance imaging (MRI) of the heart and multidetector computed tomography (MDCT); positron emission tomography/CT (PET/CT) helps to assess active vascular inflammation in Takayasu arteritis. Our review offers a unique approach using the integration of the proposed classification criteria for common systemic childhood vasculitides with their most frequent imaging findings, along with differential diagnoses and an algorithm for diagnosis based on common findings. It should help radiologists and clinicians reach an early diagnosis, therefore facilitating the ultimate goal of proper management of affected children.

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“…The endothelium expresses surface molecules that allow leucocytes and platelets to adhere, and some of the adherent inflammatory cells penetrate the vessel wall. Local expression of mediators attracts further inflammatory cells and increases vessel permeability [6]. In addition, Th17/T reg imbalance is observed in patients with acute-phase KD.…”

Section: Discussionmentioning

confidence: 99%

A Case of Complete Adult-Onset Kawasaki Disease: A Review of Pathogenesis and Classification

et al. 2015

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Kawasaki disease (KD) is an acute systemic vasculitis that occurs primarily in children and rarely in adults, possibly after bacterial or viral infections in genetically susceptible hosts. KD may frequently be undiagnosed especially in adult patients without the presence of all the classical clinical criteria (incomplete or atypical KD). In addition, many differential diagnoses could be considered. Here, we report a case of KD in an adult patient with clinical features characteristic of the classical form. KD requires a long-term management in both paediatric and adult patients, in order to avoid complications that could follow both the acute and retrospective diagnoses of KD.

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Update on Kawasaki disease: Epidemiology, aetiology and pathogenesis

Cited by 67 publications

References 65 publications

Your Viral Past: A Comprehensive Method for Serological Profiling to Explore the Human Virome

Your Viral Past: A Comprehensive Method for Serological Profiling to Explore the Human Virome

Imaging of systemic vasculitis in childhood

A Case of Complete Adult-Onset Kawasaki Disease: A Review of Pathogenesis and Classification

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