Update on outcomes research for cleft lip and palate

Shaye, David A.

doi:10.1097/moo.0000000000000064

Cited by 25 publications

(6 citation statements)

References 40 publications

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“…Outcomes are most typically measured through physician‐centered means that focus on function, aesthetics, and rate of complications, but patient quality‐of‐life (QOL) outcome measures offer a different method of determining successful treatment. Patient QOL outcome measures include self‐image, integration in society, functional status, and speech and aesthetic perceptions (Munz et al, ; Shaye, ). Additionally, studies using a sample population and health utility assessment scores have equated the perceived level of disability associated with being born with CL/P or CP as similar to being born with monocular blindness (Sinno et al, ).…”

Section: Outcomes and Quality Of Lifementioning

confidence: 99%

Cleft palate: A clinical review

Shkoukani

Lawrence

Liebertz

et al. 2014

Birth Defects Research Pt C

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Orofacial clefts, including cleft palates (CP), are one of the most common birth defects. CP have a multiplicity of effects on the individual and society in terms of economic costs, loss of productivity, psychosocial effects, and increased morbidity and mortality at all stages of life. Embryological development of the palate is well delineated, with developments in the last decade regarding the biomolecular processes involved. Etiology is complex, involving a number of genetic and environmental factors. Various techniques can be employed for the repair of CP, depending on whether the cleft is of the primary or secondary palate, the width of the cleft, whether lengthening of the palate is necessary, and with regard to concerns of disruption of midfacial growth. All surgical techniques have the goals of restoring functional speech, swallowing, and aesthetics. A multidisciplinary team is necessary for the long-term pre- and postoperative care of CP patients to handle complications, associated anomalies, and to optimize function and quality of life.

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Section: Outcomes and Quality Of Lifementioning

confidence: 99%

Cleft palate: A clinical review

Shkoukani

Lawrence

Liebertz

et al. 2014

Birth Defects Research Pt C

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“…Genetic and environmental factors speci c to each population could in uence these differences, requiring further exploration. [39]. In most cases, the surgical approach is entirely based on the personal preference of the surgeon, and most surgical centers have their own technique of choice [40].…”

Section: Resultsmentioning

confidence: 99%

Epidemiological, clinical and therapeutic aspects of cleft lip and palate in the Democratic Republic of Congo: about 1666 cases

Médard,

Onalongombe,

MEKONEN

et al. 2024

Preprint

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Introduction: Cleft lip and/or palate (CLP) are congenital malformations which mainly affect the upper lip and/or palate and are the most common malformations of the orofacial sphere. The objective of the present study was to describe the epidemiological, clinical and therapeutic profile of cleft lip and palate patients managed in the Democratic Republic of Congo (DRC). Material and Methods a retrospective descriptive study of 1666 patients with cleft lip and palate collected in 20 provinces of the DRC and managed between January 2017 and June 2022. The variables studied were epidemiological, anatomo-clinical and therapeutic. Results The mean age of patients seeking care was 11.6 years. The male predominance was (58.6%). A family history of CLP was found in 4.3% of cases and the association of CLP with other visible congenital malformations was identified in 1.5%. Isolated cleft lips were (66.1%) and palates (2.6%) of cases. Combinations involving cleft lip, palate and alveoli were observed respectively as following in terms of frequency: cleft lip-alveolar (15.7%), cleft lip-alveolar-palatal (10.6%) and cleft lip-palate (4.9%). The left side cleft was more common. Cheiloplasty was the most common repair procedure for cleft lip (81.4%) and the isolate palatoplasty was performed for 2.6% cleft palate. Conclusion In the DRC, CLP are common, with male predominance and often treated late. Cleft lips occur more commonly than cleft palates.

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“…There are advocates for cleft lip repair over a range of time frames, from the neonatal period to 5 to 6 months of age 19,20 (Level V evidence). Intrauterine repair has been piloted using animal models based on the potential benefit of no scar formation 21,22 (Level V evidence); however, this has not been seriously pursued in humans, as the theoretic benefits do not outweigh the risks of exposing both the mother and fetus to this procedure.…”

Section: Timingmentioning

confidence: 98%