Update on osteoporosis therapy

Abstract

Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes a person to increased fracture risk. Fractures are often associated with increased morbidity, higher mortality, loss of function and even psychological consequences. Pharmacotherapeutic interventions (e.g., bisphosphonates, selective estrogen receptor modulators, calcitonin, and teriparatide) in women with postmenopausal osteoporosis provide substantial reduction in fracture risk over and above risk reduction with calcium and vitamin D supplementation alone. The importance of nutritional support along with an appropriate exercise regimen, avoiding smoking and excessive alcohol use is to be emphasized along with the pharmacologic approach to osteoporosis. Despite the effectiveness of therapy with pharmacologic agents, most patients who start therapy do not remain on treatment for more than 1 year.

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

“…The resulting bone loss is associated with increased fractures, morbidity, and mortality [1]. During the past 20 years, several new pharmacologic therapies, including antiresorptive (anti-remodeling) agents that are potent inhibitors of osteoclast activity and anabolic therapies that stimulate bone formation, have been developed for the treatment of this disease [2][3][4].…”

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

“…The resulting bone loss is associated with increased fractures, morbidity, and mortality [1]. During the past 20 years, several new pharmacologic therapies, including anti-resorptive (antiremodeling) agents that are potent inhibitors of osteoclast activity and anabolic therapies that stimulate bone formation, have been developed for the treatment of this disease [2][3][4].…”

Live Old Age with Serenity, in Good Health

“…Osteoporosis is a disease that causes a reduction in bone density that occurs when adequate amounts of calcium are not taken, an element contained mainly in milk and derived products. Without the right calcium intake, one of the main constituents of bone tissue would be missing [76][77][78][79].…”