Update on morphea

Fett, Nicole; Werth, Victoria P.

doi:10.1016/j.jaad.2010.05.045

Cited by 335 publications

(271 citation statements)

References 73 publications

(133 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Morphea has a wide range of clinical presentations and courses [3]. Although in the vast majority of cases there is no internal organ involvement, the fibrotic process may extend into and affect deep structures such as the hypodermis, muscles, joints and bones, causing severe disfigurement and morbidity [3]. Furthermore, morphea of the head and face (especially the linear variant) may also be associated with ocular as well as central nervous system anomalies [5,6,7,8,9,10,11,12].…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of morphea remains elusive. Multiple mechanisms have been implicated, such as autoimmunity, infection, drugs, radiation and microchimerism [3,4]. Clinically, various types of morphea are distinguished, such as plaque morphea, bullous morphea, deep morphea and linear morphea.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, various types of morphea are distinguished, such as plaque morphea, bullous morphea, deep morphea and linear morphea. The latter also encompasses morphea en coup de sabre and Parry-Romberg syndrome affecting the scalp and face with potentially devastating complications [3,5,6,7,8,9,10,11]. Whilst in almost all cases the sclerosing process exclusively affects the skin, there are anecdotal cases in which associated mucosal involvement has been described [12,13,14,15,16,17,18,19].…”

Section: Introductionmentioning

confidence: 99%

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Oral Mucosal Morphea: A New Variant

et al. 2012

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Morphea is a cutaneous disorder characterized by an excessive collagen deposition. While in almost all cases the sclerosing process exclusively affects the skin, there are anecdotal cases in which associated mucosal involvement has been described. We here report the case of a woman developing a whitish indurated plaque over the left upper vestibular mucosa and hard palate leading to dental mobility and exposure of the roots of several teeth. Cone beam computed tomography of the left maxilla showed bone resorption involving the upper cuspid to the second molar region with widened periodontal ligament spaces, while light microscopy studies demonstrated epithelial atrophy and fibrosis of the dermis extending into the submucosa with hyalinization of subepithelial collagen. Our observation expands the spectrum of clinical presentations of morphea and provides the first example of isolated oral morphea. Its recognition is important to avoid significant local complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oral Mucosal Morphea: A New Variant

et al. 2012

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“…Deep morphea/morphea profunda is uncommon in both adults and children. The plaques of morphea most commonly develop on the trunk and are between 2 and 15 cm in diameter [5,6]. In our cases, plaque type was noted in most of the patients 83%.…”

Section: Discussionmentioning

confidence: 51%

Morphea in Saudi Arabia, a Clinical Study of 64 Patients

Alanazi¹

2017

CRDOA

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Morphea is a cutaneous disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissue or both. Clinically, it is classified into circumscribed, generalized including coalescent plaque and pansclerotic, linear, mixed and rarely guttate type. Morphea can present with laboratory abnormalities including positive antinuclear antibodies. Here we represent a clinical review of morphea in Saudi Arabia.

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