Update on Management of Squamous Cell Esophageal Cancer

Waters, John K.; Reznik, Scott I.

doi:10.1007/s11912-021-01153-4

Cited by 102 publications

(80 citation statements)

References 120 publications

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“…Nach einer endoskopischen Resektion sollen Nachkontrollen nach 3 Monaten und anschließend für 2 Jahre halbjährlich durchgeführt werden. Ansonsten erfolgt die Nachsorge zu Beginn in kurzfristigen Abständen und symptomorientiert, um frühe Rezidive und Funktionsstörungen zu erkennen [9].…”

Section: Endoskopisches Screeningunclassified

Prävention gastrointestinaler Tumoren

Teufel¹,

Quante²,

Kandulski³

et al. 2022

Gastroenterologie up2date

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Section: Endoskopisches Screeningunclassified

Prävention gastrointestinaler Tumoren

Teufel¹,

Quante²,

Kandulski³

et al. 2022

Gastroenterologie up2date

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“…Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal cancer worldwide [ 4 ]. Due to the absence of typical symptoms in the early stage, patients who have ESCC are always detected at a late stage in the disease's progression [ 5 , 6 ]. On the other hand, metastasis is one of the primary causes that leads to recurrence following surgical therapy, which ultimately results in the failure of the therapeutic attempt [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

MIR548P and TRAV39 Are Potential Indicators of Tumor Microenvironment and Novel Prognostic Biomarkers of Esophageal Squamous Cell Carcinoma

Tang

Wang

et al. 2022

Journal of Oncology

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Esophageal squamous cell carcinoma (ESCC) remains a common aggressive malignancy in the world. Multiple studies have shown evidence to support the hypothesis that certain functional genes that are engaged in the microenvironment of tumors played a role in the progression of ESCC. Thus, to better analyze the prognostic values of important genes in ESCC, there is an immediate need for an in-depth research study. From the TCGA database, the RNA-seq data and clinical features of 163 ESCC patients were obtained. Using the ESTIMATE technique, we were able to calculate the ImmuneScore, the StromalScore, and the ESTIMATEScore for each ESCC sample. The samples from the ESCC were split up into high score and low score groups based on the median of the various scores. In this study, ImmuneScore, StromalScore, and ESTIMATEScore were not found to be linked with overall survival of ESCC patients, according to our findings. Higher StromalScores were linked to more advanced T stages and clinical stages. The intersection analysis that was exhibited by the use of a Venn diagram indicated that there was a total of 944 upregulated genes that shared the same high score in both the ImmuneScore and the StromalScore and that there was 0 downregulated gene that shared the same low score. Survival experiments confirmed MIR548P and TRAV39 as critical prognostic biomarkers for ESCC patients. Importantly, we found that TRAV39 expression was positively associated with T cell CD4 memory activated while negatively associated with B cell memory, dendritic cells activated, and mast cells activated. In addition, we found that MIR548P expression was negatively associated with mast cells activated while positively associated with T cell CD4 memory activated. Overall, we identified MIR548P and TRAV39 as new modulators for ESCC, affecting the immune microenvironment of ESCC patients and may be a target of immunotherapy.

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“…However, the incidence of surgery-related complications is still relatively high and patient’s quality of life declines significantly postoperatively despite of the great advances in the surgical techniques in recent years ( 6 , 7 ). With the improvement of the general public’s health awareness, the early screening of esophageal carcinoma is becoming more and more popular ( 8 , 9 ). As a result, the proportion of superficial esophageal carcinoma which is confined to the mucosa among all esophageal cancer cases is also continuing increasing ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Long-Term Survival Between cT1N0 Stage Esophageal Cancer Patients Receiving Endoscopic Dissection and Esophagectomy: A Meta-Analysis

Wang²,

Jian³

2022

Front. Surg.

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BackgroundEndoscopic dissection (ED) shows relatively high clinical value in early esophageal cancer (cT1N0) such as lower incidence of postoperative complications and hospitalization costs and enhanced recovery. However, whether ED still has certain advantages over esophagectomy in terms of long-term survival remains unclear.PurposeThe aim of this meta-analysis was to compare the long-term outcomes of ED and surgery in the treatment of cT1N0 esophageal cancer.MethodsSeveral electronic databases including the PubMed, EMBASE, Web of Science and Cochrane Library databases were searched up to April 7, 2022 for studies which compared the overall survival (OS) and disease-specific survival (DSS) of cT1N0 esophageal cancer patients receiving the ED or esophagectomy. The hazard ratios (HRs) and 95% confidence intervals (CIs) were combined and all statistical analysis was conducted through STATA 15.0 software.ResultsA total of 12 studies involving 3,732 patients were enrolled. No significant difference in the OS between ED and surgery groups was observed (HR = 0.78, 95% CI, 0.59–1.04, p = 0.089). However, the DSS of the ED group was significantly longer than that of the surgery group (HR = 0.56, 95% CI, 0.39–0.82, p = 0.003).ConclusionIn overall, the current evidence manifested that the long-term survival of cT1N0 esophageal cancer patients undergoing ED was not worse than that of patients undergoing esophagectomy. ED may be considered as the primary treatment for cT1N0 esophageal carcinoma patients.

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Update on Management of Squamous Cell Esophageal Cancer

Cited by 102 publications

References 120 publications

Prävention gastrointestinaler Tumoren

Prävention gastrointestinaler Tumoren

MIR548P and TRAV39 Are Potential Indicators of Tumor Microenvironment and Novel Prognostic Biomarkers of Esophageal Squamous Cell Carcinoma

Comparison of Long-Term Survival Between cT1N0 Stage Esophageal Cancer Patients Receiving Endoscopic Dissection and Esophagectomy: A Meta-Analysis

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