Update on lymphoproliferative disorders of the gastrointestinal tract: disease spectrum from indolent lymphoproliferations to aggressive lymphomas

Montes‐Moreno, Santiago; King, Rebecca; Oschlies, Ilske; Ponzoni, Maurilio; Goodlad, John R.; Dotlić, Snježana; Traverse-Gléhen, Alexandra; Ott, German; Ferry, Judith A.; Calaminici, Maria

doi:10.1007/s00428-019-02704-8

Cited by 36 publications

(35 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The infiltrate can be easily overlooked, if appropriate immunohistochemical and molecular analyses are not performed. A misleading aberrant expression of B-cell markers, such as CD20, has been reported in one case of ITLPD by Wang et al [9]. It needs to be emphasized that ITLPD diagnosis always requires clonality testing.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case

et al. 2020

View full text Add to dashboard Cite

Background Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract is a rare low-grade clonal lymphoid proliferation, included as a provisional entity in the current World Health Organization classification. The disease is generally localized to the gastrointestinal tract, mainly small bowel and colon. Involvement of other organs is infrequently reported. The majority of patients show a protracted clinical course with persistent disease. A prolonged survival, even without treatment, is common. Case presentation A 28-year-old woman had a 2-year history of dyspepsia and lactose intolerance. Autoimmune diseases and celiac disease were excluded. No gross lesions were identified by endoscopy. Multiple gastric biopsies showed a small-sized lymphoid infiltrate, expanding the lamina propria, with a non-destructive appearance. The lymphoid cells were positive for CD3, CD4, CD5, CD7 and negative for CD20, CD8, CD56, CD103, PD1, CD30, ALK1, CD10, BCL6, perforin, TIA-1, Granzyme B and Epstein-Barr virus-encoded RNA. KI-67 index was low (5%). Molecular analysis revealed a clonal T-cell receptor γ rearrangement. Bone marrow was microscopically free of disease, but molecular testing identified the same T-cell receptor γ rearrangement present in the gastric biopsies. After the diagnosis of indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, the patient received steroid therapy, only for 2 months. She is alive, with a stable disease restricted to the stomach, at 12 months from diagnosis. Conclusions Indolent T-cell lymphoproliferative disorder is usually a disease of adulthood (median age: 51 yrs). The small bowel and colon are the sites most commonly involved. Our case occurred in a young woman and affected the stomach, sparing small intestine and colon. Clonality testing identified involvement of bone marrow, a site infrequently affected in this disease. Our aim is focusing on the main diagnostic issues. If appropriate immunostainings and molecular analysis are not performed, the subtle infiltrate may be easily overlooked. The risk of misdiagnosis as more aggressive lymphomas, causing patient overtreatment, needs also to be considered.

show abstract

Section: Discussionmentioning

confidence: 94%

“…Dissemination to other organs can be observed with disease progression [1,4]. Bone marrow involvement has been infrequently reported [5,9,10]. Higher-grade T-cell lymphomas may rarely develop in a subset of cases [1].…”

Section: Discussionmentioning

confidence: 99%

Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case

et al. 2020

View full text Add to dashboard Cite

show abstract

“…CD30 expression is rarely seen in type II RCD, and is considered to be a sign of progression to EATL. 8,178 M E I T L MEITL is a lymphoma derived from intraepithelial lymphocytes. It is unrelated to CD, and is composed of medium-sized cells with round nuclei and pale cytoplasm, featuring epitheliotropism to the adjacent mucosa and lacking the inflammation and necrosis characteristic of EATL.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…[204][205][206] NKCE is a rare disease, with <50 cases documented so far (reviewed in Dargent et al; see references therein). 178,[203][204][205][206][207][208][209] Most cases occurred in middle-aged to older individuals, who were either asymptomatic or presented with mild and rather nonspecific GI symptoms. The majority of the cases occurred in the stomach, duodenum, or several upper GI sites, or involved both the upper and lower GI mucosa.…”

Section: Differential Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in upper gastrointestinal lymphomas: molecular updates and diagnostic implications

2020

View full text Add to dashboard Cite

Approximately one‐third of extranodal non‐Hodgkin lymphomas involve the gastrointestinal (GI) tract, with the vast majority being diagnosed in the stomach, duodenum, or proximal small intestine. A few entities, especially diffuse large B‐cell lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue, represent the majority of cases. In addition, there are diseases specific to or characteristic of the GI tract, and any type of systemic lymphoma can present in or disseminate to these organs. The recent advances in the genetic and molecular characterisation of lymphoid neoplasms have translated into notable changes in the classification of primary GI T‐cell neoplasms and the recommended diagnostic approach to aggressive B‐cell tumours. In many instances, diagnoses rely on morphology and immunophenotype, but there is an increasing need to incorporate molecular genetic markers. Moreover, it is also important to take into consideration the endoscopic and clinical presentations. This review gives an update on the most recent developments in the pathology and molecular pathology of upper GI lymphoproliferative diseases.

show abstract

Klassifikation peripherer T-Zell-Lymphome

Fend¹,

Quintanilla-Martı́nez²,

Klapper³

2023

Pathologie

View full text Add to dashboard Cite

Update on lymphoproliferative disorders of the gastrointestinal tract: disease spectrum from indolent lymphoproliferations to aggressive lymphomas

Cited by 36 publications

References 53 publications

Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case

Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case

Recent advances in upper gastrointestinal lymphomas: molecular updates and diagnostic implications

Klassifikation peripherer T-Zell-Lymphome

Contact Info

Product

Resources

About