Update on Imaging Modalities for Ocular Surface Pathologies

Alvarez, Osmel P.; AlBayyat, Ghada; Karp, Carol L.

doi:10.1007/s40135-021-00265-1

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…Ultrasound biomicroscopy is most applicable in evaluating intraocular tumor extension and metastatic spread 20 . It may be an adjunctive imaging modality to high-resolution AS-OCT 21 . Non-invasive anterior segment imaging modalities are useful in the diagnostic process and for monitoring the response to topical pharmacotherapy and early identification of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis

Kozma

Dömötör

Csutak

et al. 2022

Sci Rep

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Ocular surface squamous neoplasia (OSSN) has different treatment modalities. Although surgical excision has been the gold standard therapeutic option, topical pharmacotherapy agents such as 5-fluorouracil (5-FU), interferon alfa-2b (IFN) and mitomycin-C (MMC) are also commonly used. The protocol was registered (CRD42021224961). Comprehensive literature research was carried out to compare topical pharmacotherapy (5-FU or IFN or MMC) to surgical excision regarding clinical success (tumor resolution), recurrence and complications in patients undergoing treatment for OSSN. From 7859 records, 7 articles were included in the qualitative and 4 in the quantitative synthesis. The outcomes of surgical excision and topical pharmacotherapy were comparable in the included articles. There were no significant differences between surgical excision and topical pharmacotherapy regarding the clinical success [odds ratio (OR): 0.785; confidence interval (CI): 0.130–4.736, P = 0.792)] and tumor recurrence (OR: 0.746; CI: 0.213–2.609; P = 0.646). The most common side effect of the different therapeutic options was dry eye. The highest rate of dry eye symptoms was reported after surgical excision (in 59%). Topical pharmacotherapy with all the 3 agents is as effective and well-tolerable as surgical excision in terms of tumor resolution, recurrence rate and side effects in all OSSN patients suggesting similar long-term clinical benefits.

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Section: Introductionmentioning

confidence: 99%

Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis

Kozma

Dömötör

Csutak

et al. 2022

Sci Rep

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Conjunctival Tumors in Children

Luong¹,

Ramasubramanian²

2023

Advances in Ophthalmology and Optometry

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The Short-term Effects of Artificial Tears on the Tear Film Assessed by a Novel High-Resolution Tear Film Imager: A Pilot Study

Antman,

Tessone,

Rios

et al. 2024

Cornea

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Purpose: The purpose of this study was to investigate the effects of artificial tears (AT) on the sublayers of the tear film assessed by a novel tear film imaging (TFI) device. Methods: The mucoaqueous layer thickness (MALT) and lipid layer thickness (LLT) of 198 images from 11 healthy participants, 9 of whom had meibomian gland disease, were prospectively measured before and after exposure to 3 different AT preparations (Refresh Plus; Retaine [RTA]; Systane Complete PF [SYS]), using a novel nanometer resolution TFI device (AdOM, Israel). Participants were assessed at baseline and at 1, 5, 10, 30, and 60 minutes after instilling 1 drop of AT during 3 sessions on separate days. Repeated-measures analysis of variances were used for comparisons with P < 0.05 considered significant. Results: For all ATs, the mean MALT was greatest 1 minute after drop instillation, with an increase of 67%, 55%, and 11% above the baseline for SYS, Refresh Plus, and RTA, respectively. The SYS formulation demonstrated the highest percentage increases in mean MALT and LLT at most postdrop time points. The MALT differences were significantly higher in the SYS than in the RTA (P = 0.014). After 60 minutes, no AT group demonstrated statistically significant changes in MALT or LLT compared with baseline. Conclusions: We report, for the first time, the effects of AT on MALT and LLT using a high-resolution TFI. A substantial acute mean MALT increase occurs 1 minute after AT instillation with all agents tested, but there were clear differences in response and durability, suggesting the benefits of choosing specific AT according to the needs of each patient.

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Update on Imaging Modalities for Ocular Surface Pathologies

Cited by 3 publications

References 58 publications

Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis

Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis

Conjunctival Tumors in Children

The Short-term Effects of Artificial Tears on the Tear Film Assessed by a Novel High-Resolution Tear Film Imager: A Pilot Study

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