Update on Glycopeptide Use in German University Hospitals

Kern, Winfried V.; Gonnermann, Christa; Strehl, Egid

doi:10.1007/s15010-004-3159-0

Cited by 9 publications

(8 citation statements)

References 52 publications

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“…This finding is disturbing and may suggest a high degree of vancomycin misuse. Recent studies conducted in Western countries showed that inappropriateness in the use of vancomycin did not exceed 40 % of guidelines recommendations even in the absence of restriction policies [10][11]. At SQUH, the prevalence of β-lactamresistant Gram-positive microorganisms and infections by MRSA, compared to what is reported in most Western countries, is low [12].…”

Section: Discussionmentioning

confidence: 97%

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Utilization Pattern of Vancomycin in a University Teaching Hospital in Oman: Comparison with International Guidelines

Za’abi¹,

Shafiq

Riyami³

et al. 2013

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 97%

“…In contrast to other hospitals in various countries, the major use of vancomycin was for surgical prophylaxis [6]. Hematology department, however, was the highest prescriber of therapeutic vancomycin, a finding similarly reported elsewhere [7,10]. It was utilized for treatment of sepsis and catheter-related infections.…”

Section: Discussionmentioning

confidence: 97%

Utilization Pattern of Vancomycin in a University Teaching Hospital in Oman: Comparison with International Guidelines

Za’abi¹,

Shafiq

Riyami³

et al. 2013

Trop. J. Pharm Res

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“…A study of glycopeptide use in German hospitals showed high consumption in the ICUs with a sharp increase in the period 1998 -2000. 13,14 The authors suggested that prophylactic and empirical indications may therefore account for more than 50% of all prescriptions, so that a substantial amount of glycopeptide prescriptions may be inappropriate. Irrespective of the reasons for such high consumption of glycopeptides, this is a matter of great concern because their excessive use enhances the risk of resistance among enterococci and staphylococci.…”

Section: Discussionmentioning

confidence: 99%

A 3 year survey on the use of antibacterial agents in five Italian hospitals

Vaccheri

Silvani

Bersaglia

et al. 2008

Journal of Antimicrobial Chemotherapy

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Background: Misuse of antimicrobial agents in hospitals may cause the emergence of resistant microorganisms, as well as increased costs and unnecessary exposure of patients to drugs. We investigated the pattern of antibiotic consumption in 2002 -04 in a sample of Italian hospitals, and compared this with antibiotic consumption data in primary healthcare in the Emilia-Romagna region. Methods:The study was carried out in five hospitals of the Emilia-Romagna region and 2002-04 drug use data were obtained from the pharmacy services. Data were analysed by clinical areas and single wards and were expressed by ATC classification and defined daily doses (DDD)/100 bed days. Prescription data of antibacterials in primary care in the same period were also analysed.Results: Antibiotic consumption increased by 18% in the 3 year period. Combinations of penicillins and b-lactamase inhibitors were the most used drugs, followed by fluoroquinolones and thirdgeneration cephalosporins. Penicillins plus b-lactamase inhibitors increased in all the clinical areas by over 40%, and fluoroquinolones sharply increased in medical units (129%). Third-generation cephalosporins remained fairly stable in paediatrics and surgery, but increased in medicine (118%). Glycopeptides accounted for 4.3% of total antibiotic consumption with a peak of 10% in intensive care units. Antibacterial prescription in primary care showed a pattern similar to that of hospitals. Conclusions:We found a considerable increase in antibiotic use over time and a marked preference for wide-spectrum antibiotics such as penicillins plus b-lactamase inhibitors, fluoroquinolones and third-generation cephalosporins; thus raising concern about appropriate use. These results could represent the basis for educational initiatives aimed at rationalizing the use of antibiotics in hospitals.

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“…The second is the MABUSE network (Medical Antibiotic Use Surveillance and Evaluation) that aims at integrating ambulatory and hospital care antibiotic use and resistance surveillance and research at regional levels. The MABUSE project initially included an interhospital comparison of antibiotic use and expenditures at university hospitals, and ambulatory care antibiotic use surveillance at the regional level [2][3][4][5][6][7][8]. In a pilot study (INTERUNI-II) using retrospective data for the years 1998 to 2000, we estimated antibiotic use density in university hospitals to be ~60 DDD/100 in the surgical services, and ~80 DDD/100 in the medical services, respectively [5].…”

Section: Introductionmentioning

confidence: 99%