Update on Genital Lesions

Rosén, Ted

doi:10.1001/jama.290.8.1001

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…Diagnosis is based on clinical background, symptoms, clinical signs, and the appearance of skin lesions in the genital area or elsewhere in the body [19, 23, 33, 34]. However, in cases where genital lesions are the only clinical finding, skin biopsy might be an option, showing the same classical histopathological characteristics of non-genital plaque psoriasis, such as Kogoj’s and Munro-Sabouraud’s collections of neutrophils, thickening of the Malpighian layer, hypogranulosis, hyperkeratosis, parakeratosis, and elongation of the papillae [3, 5, 16, 17, 35], but with the slight difference that this findings may be less evident in vulvar and penile psoriatic lesions [17, 29].…”

Section: Discussionmentioning

confidence: 99%

Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

Guglielmetti

Conlledo

Bedoya

et al. 2012

Dermatol Ther (Heidelb)

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IntroductionInverse psoriasis is a rare form of psoriasis that affects between 3% and 7% of the patients with psoriasis. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. There are few evidence-based studies about the treatment of intertriginous psoriasis involving genital skin folds.Case PresentationThe authors present a 42-year-old female patient with erythematous plaques in the vulva, groin, and perianal region. The patient had previously received a broad range of topical and systemic therapies that had to be discontinued due to ineffectiveness or side effects. She was treated with 100 mg dapsone daily for 10 months, showing a significant improvement of her cutaneous and mucous lesions. Complete clearance of psoriatic lesions was observed after 4 weeks of treatment. She has remained in remission for up to 2 years, using only topical therapy with tacrolimus 0.1% and calcipotriol.DiscussionGenital psoriasis is a skin disease that causes great discomfort. It is important to include examination of the genital region and to adopt this conduct in daily clinical practice. Research in this field is still poor, making no discrimination between flexural and genital psoriasis, and is based on case series and expert opinion; therefore, empirical recommendations for the treatment of genital psoriasis remain. Dapsone has been shown to be an effective and convenient alternative for the treatment of inverse psoriasis in genital skin folds, which can provide effective control of the disease. Further studies are required to determine the efficacy and safety of current therapies, and to decide whether dapsone therapy should be considered in the management of this form of psoriasis when topical and other systemic agents are not effective.

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Section: Discussionmentioning

confidence: 99%

Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

Guglielmetti

Conlledo

Bedoya

et al. 2012

Dermatol Ther (Heidelb)

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“…Psoriatic lesions at the genitalia present mostly as well-demarcated, brightly erythematous, thin plaques without scaling (Fig. 1), which is typical in other areas because of maceration [4]. If scales are present, they are observed only on more keratinised parts of the genital skin [5].…”

Section: Symptomsmentioning

confidence: 99%

Genital psoriasis: a hidden multidisciplinary problem — a review of literature

et al. 2016

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Genital psoriasis is a variety of autoimmune dermatological disease -psoriasis with relapsing-remitting course, which can have an onset in all age groups. It is most often diagnosed at an advanced stage. Genital psoriasis is considered an embarrassing condition and is often misjudged as a sexually transmitted disease or allergic reaction due to low social awareness of the disease. The manifestations of genital psoriasis may differ from typical genital dermatoses and with symptoms such as itch, erythroderma and vaginal discharge may mimic other diseases at an early stage. The diagnosis and treatment of genital psoriasis may be difficult and often requires a multidisciplinary approach. The aim of this article is to present the literature review of genital psoriasis concentrating on the clinical presentation, treatment and influence on the quality of patients' life and sexual activity disorders.

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“…Psoriatic lesions on the genital skin often present as well-demarcated, brightly erythematous, thin plaques and usually lack, due to maceration, the typical scaling that is apparent on other parts of the body (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). However, scales may be seen on the more keratinised regions of the genital skin (34,40,41).…”

Section: Clinical Presentation [Loe: 5]mentioning

confidence: 99%

Genital Psoriasis: A Systematic Literature Review on this Hidden Skin Disease

Meeuwis¹,

Hullu²,

Massuger³

et al. 2011

Acta Derm Venerol

143

133

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It is well known that the genital skin may be affected by psoriasis. However, little is known about the prevalence and clinical appearance of genital psoriasis, and genital skin is often neglected in the treatment of psoriatic patients. We performed an extensive systematic literature search for evidence-based data on genital psoriasis with respect to epidemiology, aetiology, clinical and histopathological presentation, diagnosis and treatment. Three bibliographical databases (PubMed, EMBASE and the Cochrane Library) were used as data sources. Fifty-nine articles on genital psoriasis were included. The results show that psoriasis frequently affects the genital skin, but that evidence-based data with respect to the efficacy and safety of treatments for genital psoriasis are extremely limited. An advised treatment paradigm for genital psoriasis, based on the levels of evidence, is: first-line: (weak) topical corticosteroids; second-line: vitamin D preparations or tar-based treatments.

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Update on Genital Lesions

Cited by 19 publications

References 29 publications

Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

Genital psoriasis: a hidden multidisciplinary problem — a review of literature

Genital Psoriasis: A Systematic Literature Review on this Hidden Skin Disease

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