Update on epidemiology, diagnosis, and treatment of pertussis

Hoppe, J. E.

doi:10.1007/bf01591352

Cited by 21 publications

(6 citation statements)

References 41 publications

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“…Methods for culture are well described (272,273,359,362,418,473,572). Although many types of culture medium have allowed the successful isolation of B. pertussis from clinical specimens, charcoal agar (Regan-Lowe agar) supplemented with 10% horse blood and cephalexin (40 mg/liter) is currently the medium of choice (572).…”

Section: Specific Diagnosis Of B Pertussis Infectionsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Specific Diagnosis Of B Pertussis Infectionsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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“…Experience with the method is one of the most important variables. Attempts at isolating B. pertussis are most likely to be successful at the end of the incubation period, during the catarrhal stage, and at the beginning of the paroxysmal (convulsive) stage of the disease (9,26,42,52,59,102). Isolation rates are negatively correlated with increasing age (high rate in infants [121]; low rate in adults [116]), with effective antimicrobial pretreatment (macrolides, co-trimoxazole, and tetracyclines but not penicillin or ampicillin [8,42,59,102]), and with the number of pertussis vaccination doses received by the patient (lower isolation rate in completely vaccinated individuals [8,35,59,102]).…”

Section: Isolation Of B Pertussismentioning

confidence: 99%

“…In view of the continuing importance and high prevalence of whooping cough in many countries, it seems appropriate to present an updated review of the laboratory methods used to diagnose this disease (52).…”

Section: Introductionmentioning

confidence: 99%

Laboratory diagnosis of pertussis: state of the art in 1997

Müller¹,

Hoppe²,

König³

1997

J Clin Microbiol

160

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“…An increasing number of adults and adolescents with waning immunity, especially in wellvaccinated populations where natural boosting has been reduced, are now susceptible to pertussis reinfection [8,[11][12][13][14]. The major cause for concern is the potential for older infected family members to serve as reservoir of infection to young infants, which has been shown in several household studies [11,12,14 -18].…”

mentioning

confidence: 99%