Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges
Paola Vargas,
Fabio A. Doctorovich,
Sebastian A. Suarez
Abstract:This review consolidates the evidence supporting endogenous HNO generation through enzymatic and non‐enzymatic pathways, emphasizing advancements in real‐time HNO sensing within living systems. Azanone (nitroxyl, HNO) is the one‐electron‐reduced congener of nitric oxide (NO•) and shares various biological actions. HNO exhibits unique properties, including positive inotropic and lusitropic effects, along with resistance to scavenging by reactive oxygen species (ROS), particularly superoxide. Research on HNO has… Show more
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