Update on Early Introduction of Peanut to Prevent Allergy Development: Challenges with Implementation

Prince, Ben T.; Stukus, David R.

doi:10.1007/s11882-019-0884-0

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Употребление аллергенов в пищу было связано с более частым развитием переносимости и толерантности к антигену, а ингаляционный и чрез кожный пути приводили к презентации антигена макрофагами T-лимфоцитам хелперам и В-лимфоцитам, что заканчивалось сенсибилизацией и продукцией специфических IgE [4]. Более того, показано, что раннее введение аллергенных продуктов способно предотвратить пищевую аллергию [5].…”

Section: выбор причинных аллергеновunclassified

Clinical case of early debut of food allergy in a child up to 6 months

Masalskiy

Smolkin²,

Smolkina

2022

Allergol. immunol. pediatr.

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Introduction: It is believed that if the child ate only a cow’s milk formula (CMF), and сow's milk allergy is the only possible at the age of <6 months. This approach leads to erroneous treatment tactics. Presentation of the clinical case: a child aged 3 months with the debut of atopic dermatitis (AtD) of light degree (on the scale of the assessment of the researcher IGA 2). The patient was fed on artificial with a CMF from 1,5 months. Infant was examined at the place of residence. The CMF was changed to full hydrolysis CMF and without examination. Additionally, cosmetics were applied to the skin as needed. The child was examined by an allergologist after 3-4 weeks of diet. Negative dynamics were observed. Atopic dermatitis has become moderately severe with secondary infection complications (IGA 3, 50% affected skin). Prick-tests with allergens of milk, eggs, wheat, fish were carried out. High sensitization to egg and controversial to cow’s milk was found. The results were clarified during enzyme immunoassay: IgE ovomucoid – 0.78 IU/ml (norm <0.3 IU/ml); cow's milk 0.01 kUA/ l; casein – 0.01 kUA / l (norm <0.1 kUA/l). Considering the infected AtD, "hydrocortisone + natamycin + neomycin" 2 times a day was used in the therapy. Cosmetics on infected foci was canceled, while maintaining the treatment of dry unaffected skin. It is recommended to limit household contacts with eggs. After 2 weeks, the rash is residual (IGA 0-1). The cow’s milk formula was returned to the diet without exacerbations of the skin process. Conclusion: The case illustrates that sensitization in children can begin and be maintained without oral ingestion of the allergen. Sensitization at the age of up to 6 months is likely with a moderate – severe recurrent course of dermatitis. A specific allergological examination can be conduct with a developed disease at an early age. Skin tests and enzyme immunoassay are applicable in infants. The appointment of a diet without examination is unreasonable and should not be used.

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Section: выбор причинных аллергеновunclassified

Clinical case of early debut of food allergy in a child up to 6 months

Masalskiy

Smolkin²,

Smolkina

2022

Allergol. immunol. pediatr.

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“…20 Should high-risk infants be pre-screened with allergy testing before introducing allergenic foods for OTI to be safe? 21 Finally, which foods should be introduced early and if more than one food is to be introduced, how can adherence to this longterm dietary intervention be achieved? 22 This review examines the extent to which recent trials address these critical questions and highlight areas where further research is required.…”

Section: F I G U R Ementioning

confidence: 99%

Overview of oral tolerance induction for prevention of food allergy—Where are we now?

Krawiec

Fisher

Toit

et al. 2021

Allergy

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Oral tolerance induction through early introduction of allergenic food has proven effective in randomized controlled trials. This new approach to weaning has been incorporated into many national and international infants' feeding guidelines. However, there are questions that require further discussion, such as, which foods should be introduced early, should the intervention be targeted to infants at high-risk or to the general population, and what is the ideal timing for early food introduction. This review examines the extent to which recent trials address these critical questions and highlights areas where further research is required.

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“… 6 However, several barriers to the implementation of updated guidelines for infant feeding for food allergy prevention have been acknowledged, including education of health professionals and health professional support of the guidelines, parental awareness and hesitancy, and existing infant feeding resources. 12 , 13 , 14 …”

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confidence: 99%