Update on Diffuse Lung Disease in Children

Vece, Timothy J.; Young, Lisa R.

doi:10.1378/chest.15-1986

Cited by 36 publications

(34 citation statements)

References 75 publications

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“…Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency Background: Diffuse lung disease is rare in children, and recent classification systems recognize that certain disorders are more prevalent in infants (Vece and Young 2016). Childhood interstitial lung disease (chILD) syndrome describes a collection of respiratory symptoms and diffuse abnormalities on imaging (Kurland et al 2013;Vece and Young 2016).…”

Section: Referencesmentioning

confidence: 99%

“…Childhood interstitial lung disease (chILD) syndrome describes a collection of respiratory symptoms and diffuse abnormalities on imaging (Kurland et al 2013;Vece and Young 2016). Increasingly, immunodeficiency and immune dysregulation syndromes are recognized as causes of chILD (Vece and Young 2016).…”

Section: Referencesmentioning

confidence: 99%

“…A recent review highlights the evolving role of WES for evaluation of diffuse lung diseases (Vece and Young 2016); recent case reports have identified genetic changes impacting CTLA4 trafficking and STAT3 signaling (Vece and Young 2016). Application of this diagnostic tool earlier in our patient's course would also have shortened time to diagnosis.…”

Section: Referencesmentioning

confidence: 99%

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Abstracts from the Immunodeficiency Canada 4th sCID Symposium

Lafleur¹

2016

LymphoSign Journal

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Section: Referencesmentioning

confidence: 99%

Section: Referencesmentioning

confidence: 99%

Section: Referencesmentioning

confidence: 99%

See 1 more Smart Citation

Abstracts from the Immunodeficiency Canada 4th sCID Symposium

Lafleur¹

2016

LymphoSign Journal

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“…Diffuse lung disease is rare in children, and recent classification systems recognize that certain disorders are more prevalent in infants (Vece and Young 2016). chILD (childhood interstitial lung disease) syndrome describes a collection of respiratory symptoms and diffuse abnormalities on imaging (Kurland et al 2013;Vece and Young 2016).…”

Section: Introductionmentioning

confidence: 99%

“…chILD (childhood interstitial lung disease) syndrome describes a collection of respiratory symptoms and diffuse abnormalities on imaging (Kurland et al 2013;Vece and Young 2016). chILD syndrome can be diagnosed if at least 3 of the following 4 criteria are present: (i) respiratory symptoms (cough, dyspnea, exercise intolerance); (ii) respiratory signs (tachypnea, adventitious sounds, retractions); (iii) hypoxemia; and (iv) diffuse abnormalities on a chest radiograph (CXR) or computed tomography (CT) scan (Kurland et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency

et al. 2017

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Introduction: Childhood interstitial lung disease (chILD) syndrome describes findings of respiratory symptoms and diffuse abnormalities on lung imaging. Immunodeficiency and immune dysregulation are increasingly recognized as potential causes of these clinical findings. Patients with CD40 ligand (CD40L) deficiency typically present with sinopulmonary and opportunistic infections secondary to impairments in both humoral and cellular immunity. chILD syndrome has not previously been reported as a presenting feature of this disease.

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Pulmonary hypertension in childhood interstitial lung disease: A systematic review of the literature

Bromley

Vizcaya

2016

Pediatric Pulmonology

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Childhood interstitial lung disease (chILD) comprises a wide heterogeneous group of rare parenchymal lung disorders associated with substantial morbidity and mortality. Pulmonary hypertension is a common comorbidity in adults with interstitial lung disease (ILD) and associated with poor survival. We aimed to systematically review the literature regarding the occurrence of pulmonary hypertension (PH) in chILD, its effect on prognosis and healthcare use, and its treatment in clinical practice. Searches of PubMed and EMBASE databases (up to February 2016), and American Thoracic Society conference abstracts (2009-2015) were conducted using relevant keywords. References from selected articles and review papers were scanned to identify further relevant articles. A total of 20 articles were included; estimates of PH in chILD ranged from 1% to 64% with estimates among specific chILD entities ranging from 0% to 43%. Comparisons between studies were limited by differences in the study populations, including the size, age range, and heterogeneous composition of the ILD case series in terms of the nature and severity of the clinical entities, and also the methods used to diagnose PH. Three studies found that among patients with chILD, those with PH had a significantly higher risk (up to sevenfold) of death compared with those without PH. Information on the treatment of pulmonary hypertension in chILD or the effect of PH on healthcare use was not available. Data on the use and effectiveness of treatments for pulmonary hypertension in chILD are required to address this area of unmet need. Pediatr Pulmonol. 2017;52:689-698. © 2016 Wiley Periodicals, Inc.

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Update on Diffuse Lung Disease in Children

Cited by 36 publications

References 75 publications

Abstracts from the Immunodeficiency Canada 4th sCID Symposium

Abstracts from the Immunodeficiency Canada 4th sCID Symposium

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency

Pulmonary hypertension in childhood interstitial lung disease: A systematic review of the literature

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