Update on diabetes diagnosis and management

Robertson, Carolyn; Drexler, Andrew; Vernillo, Anthony T.

doi:10.14219/jada.archive.2003.0368

Cited by 12 publications

(16 citation statements)

References 27 publications

(17 reference statements)

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“…2,4,6,9,10,18 The oral cavity may show the first signs or symptoms of an undiagnosed or poorly controlled diabetic condition. 2,10,12,18 Other findings characteristic of DM are accelerated tooth eruption until 10 years of age, greater gingival bleeding 23 when probing and a higher prevalence of caries.…”

Section: Discussionmentioning

confidence: 99%

“…24,25 Glycemic control in DM management is a key to reducing the impact of acute oral infections and microvascular complications, 2,5,6,8,9,14,25 and for diabetes patients under good medical control, all dental procedures can be performed. 2,6,10,13 A diabetes control and complications trial study revealed that long-term complications can be reduced by 54% to 76% if DM is managed properly, 26 and systemic and oral complications are more likely the longer the disease lasts and remains out of control.…”

Section: Discussionmentioning

confidence: 99%

“…7 Usually, type 1 affects children, destroying pancreatic beta cells and leading to an absolute insulin deficiency, while type 2 mostly affects adults older than 40 years and is frequently associated with overweight and with obesity. 2,3,8,9 DM buccal manifestations include periodontal and dental tissue infections, salivary gland dysfunction, and greater susceptibility to viral and fungal infections. 6,[9][10][11][12] The production of less saliva results in greater susceptibility to mucositis, peeling, and ulcerations.…”

Section: Introductionmentioning

confidence: 99%

“…2,3,8,9 DM buccal manifestations include periodontal and dental tissue infections, salivary gland dysfunction, and greater susceptibility to viral and fungal infections. 6,[9][10][11][12] The production of less saliva results in greater susceptibility to mucositis, peeling, and ulcerations. 6 This report presents the complications of treatment with a Hass rapid maxillary expander (RME) in a patient with diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

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Maxillary ulceration resulting from using a rapid maxillary expander in a diabetic patient

Maia¹,

Monini²,

Jacob³

et al. 2011

The Angle Orthodontist

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maxillary ulceration resulting from using a rapid maxillary expander in a diabetic patient

Maia¹,

Monini²,

Jacob³

et al. 2011

The Angle Orthodontist

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“…Attempts by the various researchers to correlate SGL with HbA1c levels have shown contradictory results. Literature shows that serum glucose concentration in patients with DM reflects HbA1c levels with significant correlation 5,[12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Diyabetli Hastalarda Tükrük Glukoz Seviyelerinin Serum Glukoz Seviyesi ve Glisemik Durum ile İlişkisi

Shanbhag¹

2014

Cukurova Medical Journal

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Purpose: Diabetes mellitus (DM) is an endocrine disease that is frequently encountered routinely by dentists. There is increased interest towards non invasive modes to diagnose this disease, one of which is Saliva. The aim of the study was to determine Salivary glucose levels in diabetic and healthy controls, to determine and compare salivary glucose levels with serum glucose in a group of diabetic subjects and matched controls and to study the correlation of salivary glucose levels and glycemic control status in diabetics and controls as determined by HbA1c values. Material and Methods:-The study sample included 200 subjects, 120 with diabetes and 80 controls aged between 5-75 years. Samples of whole saliva and serum were obtained for determining salivary glucose level (SGL), Blood glucose level (BGL) and glycosylated hemoglobin (HbA1c). Serum and salivary glucose was assayed by use of Glucose Oxidase Peroxidase method. Glycosylated hemoglobin was determined by Ion Exchange Resin method. Results:-Salivary glucose levels were significantly higher in diabetics than in controls. Significant positive correlation was found between SGL and BGL in diabetics as well as controls. No positive correlation was found between SGL and HbA1c, nor was any correlation found between SGL, age, sex, and duration of disease. Conclusion:-Saliva can be used as a routine potential diagnostic tool in assessing diabetes mellitus, the most prevalent among Indian population. It is a simple and non invasive technique in screening and monitoring of this disease. Repeated painful pricks, hazard of getting infections, complications in hemophiliac patients and various other disadvantages that involve the blood tests currently used for diagnosis and monitoring of this widely prevalent Diabetes mellitus disease, can be replaced by non invasive tests involving Saliva, which is also a cost effective.

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Sulfonylurea receptor as a target for molecular imaging of pancreas beta cells with 99mTc-DTPA-glipizide

Kohanim

Kong

et al. 2012

Ann Nucl Med

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Objective This study was aimed to assess pancreas beta cell activity using 99mTc-diethyleneaminepentaacetic acid-glipizide (DTPA-GLP), a sulfonylurea receptor agent. The effect of DTPA-GLP on the blood glucose level in rats was also evaluated. Methods DTPA dianhydride was conjugated with GLP in the presence of sodium amide, yielding 60%. Biodistribution and planar images were obtained at 30–120 min after injection of 99mTc-DTPA-GLP (1 mg/rat, 0.74 and 11.1 MBq per rat, respectively) in normal female Fischer 344 rats. The control group was given 99mTc-DTPA. To demonstrate pancreas beta cell uptake of 99mTc-DTPA-GLP via a receptor-mediated process, a group of rats was pretreated with streptozotocin (a beta cell toxin, 55 mg/kg, i.v.) and the images were acquired at immediately—65 min on day 5 post-treatment. The effect on the glucose levels after a single administration (ip) of DTPA-GLP was compared to glipizide (GLP) for up to 6 h. Results The structure of DTPA-GLP was confirmed by NMR, mass spectrometry and HPLC. Radiochemical purity assessed by ITLC was >96%. 99mTc-DTPA-GLP showed increased pancreas-to-muscle ratios, whereas 99mTc-DTPA showed decreased ratios at various time points. Pancreas could be visualized with 99mTc-DTPA-GLP in normal rat, however, 99mTc-DTPA has poor uptake suggesting the specificity of 99mTc-DTPA-GLP. Pancreas beta cell uptake could be blocked by pre-treatment with streptozotocin. DTPA-GLP showed an equal or better response in lowering the glucose levels compared to the existing GLP drug. Conclusions It is feasible to use 99mTc-DTPA-GLP to assess pancreas beta cell receptor recognition. 99mTc-DTPA-GLP may be helpful in evaluating patients with diabetes, pancreatitis and pancreatic tumors.

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Update on diabetes diagnosis and management

Cited by 12 publications

References 27 publications

Maxillary ulceration resulting from using a rapid maxillary expander in a diabetic patient

Maxillary ulceration resulting from using a rapid maxillary expander in a diabetic patient

Diyabetli Hastalarda Tükrük Glukoz Seviyelerinin Serum Glukoz Seviyesi ve Glisemik Durum ile İlişkisi

Sulfonylurea receptor as a target for molecular imaging of pancreas beta cells with 99mTc-DTPA-glipizide

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