Update on dermatomyositis in adults

Schlecht, Nora; Sunderkötter, Cord; Niehaus, Sabine; Nashan, Dorothée

doi:10.1111/ddg.14267

Cited by 20 publications

(34 citation statements)

References 59 publications

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“…The link between anti-TIF1γ titers and paraneoplastic DM has been reported in the literature [12]. Tests for this antibody are positive in 14-93 % of cases of paraneoplastic DM [3,6,12,13]. In our patient collective, anti-TIF1γ assays were positive in 71 % of paraneoplastic DM cases and, moreover, the positive predictive value was found to be 100 %.…”

Section: Clinical Lettersupporting

confidence: 71%

Paraneoplastic dermatomyositis in adults: an underestimated association?

Kyprianou¹,

Zutt²,

Kaune³

2022

J Deutsche Derma Gesell

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Section: Clinical Lettersupporting

confidence: 71%

Paraneoplastic dermatomyositis in adults: an underestimated association?

Kyprianou¹,

Zutt²,

Kaune³

2022

J Deutsche Derma Gesell

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“…In addition, Fardet et al state that the probability of developing cancer-associated DM is increased, if the time between initial manifestation and initial diagnosis is less than four months [6]. A potential cause may be that DM patients with malignancy may, individually, often exhibit acute and more severe skin-related symptoms and rather refractory muscle-related symptoms [8,9,15]. The reported laboratory measurements were not available for all patients.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of dermatomyositis patients with and without associated malignancy

Lauinger

Ghoreschi

Volc

2021

J Deutsche Derma Gesell

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Background: Dermatomyositis belongs to the rare idiopathic, inflammatory myositis group. A previously postulated link between some cases of dermatomyositis and malignancy has been established in recent years. Criteria suggestive of a malignancy association are still being explored. Patients and Methods:We retrospectively analyzed data from 63 patients with dermatomyositis over a period of 15 years. Results:The following criteria argue for cancer-associated dermatomyositis: older age (> 52 years [P = 0.001], > 65 years [P = 0.002], ≥ 75 years [P = 0.002]), shorter time between manifestation and diagnosis of dermatomyositis (malignancy group: 59 days vs. non-malignancy group: 137 days [P = 0.022]), typical skin involvement such as Gottron sign (P = 0.045), centrofacial erythema (P = 0.036) and typical erythema on the upper arms and forearms (P = 0.019), oropharyngeal involvement (P = 0.015) and increased ALT (P = 0.031). The following criteria argue for non-cancer-associated dermatomyositis: younger age (≤ 52 years [P = 0.001], 40-65 years [P = 0.045]) and pruritus (P = 0.026). Conclusions:The aforementioned criteria have been documented in the literature, but reported findings are heterogenous concerning the suitability of their markers for malignancy association. Small study populations, few prospective controlled studies, summarization of different forms of myositis and inconsistent use nomenclature contribute to biased results. Our study aims to make an important contribution toward the identification of risk factors in cancer-associated dermatomyositis.

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“…DM is a rare idiopathic inflammatory myopathy. The lesions mainly involve the skin and muscles, and are often accompanied by systemic complaints such as pulmonary interstitial lesions, dysphagia, tumors, and diastolic dysfunction ( 187 ). Muscle biopsy specimens of patients with DM are histopathologically characterized by perifascicular atrophy (PFA) and inflammatory cell infiltration ( 188 ).…”

Section: Role Of Pyroptosis In Autoimmune Diseasesmentioning

confidence: 99%

Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target

You

Zeng

et al. 2022

Front. Immunol.

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Autoimmune diseases are a group of heterogeneous diseases with diverse clinical manifestations that can be divided into systemic and organ-specific. The common etiology of autoimmune diseases is the destruction of immune tolerance and the production of autoantibodies, which attack specific tissues and/or organs in the body. The pathogenesis of autoimmune diseases is complicated, and genetic, environmental, infectious, and even psychological factors work together to cause aberrant innate and adaptive immune responses. Although the exact mechanisms are unclear, recently, excessive exacerbation of pyroptosis, as a bond between innate and adaptive immunity, has been proven to play a crucial role in the development of autoimmune disease. Pyroptosis is characterized by pore formation on cell membranes, as well as cell rupture and the excretion of intracellular contents and pro-inflammatory cytokines, such as IL-1β and IL-18. This overactive inflammatory programmed cell death disrupts immune system homeostasis and promotes autoimmunity. This review examines the molecular structure of classical inflammasomes, including NLRP3, AIM2, and P2X7-NLRP3, as the switches of pyroptosis, and their molecular regulation mechanisms. The sophisticated pyroptosis pathways, including the canonical caspase-1-mediated pathway, the noncanonical caspase-4/5/11-mediated pathway, the emerging caspase-3-mediated pathway, and the caspase-independent pathway, are also described. We highlight the recent advances in pyroptosis in autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, Sjögren’s syndrome and dermatomyositis, and attempt to identify its potential advantages as a therapeutic target or prognostic marker in these diseases.

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Update on dermatomyositis in adults

Cited by 20 publications

References 59 publications

Paraneoplastic dermatomyositis in adults: an underestimated association?

Paraneoplastic dermatomyositis in adults: an underestimated association?

Characteristics of dermatomyositis patients with and without associated malignancy

Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target

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