Update on cryotherapy for prostate cancer in 2006

Mouraviev, Vladimir; Polascik, Thomas J.

doi:10.1097/01.mou.0000193393.54598.9f

Cited by 63 publications

(33 citation statements)

References 45 publications

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“…However, it has only been recently considered as a potential ablation technique to treat several diseases in humans [Mir, 2010]. Most of the ablation techniques already available are based on thermal effects because they are based on cold (cryosurgery [Onik et al, 1993;Mouraviev and Polascik, 2006]) or heat application (ablathermia using radiofrequency [de Baère et al, 2006;Martin, 2006], microwaves [Ozaki et al, 2003] or ultrasonic waves [Yang et al, 1992]). IRE does not need Joule heating or any thermal effect to destroy cells.…”

Section: Bases Of Irreversible Electroporationmentioning

confidence: 99%

Microsecond and nanosecond electric pulses in cancer treatments

Breton¹,

Mir²

2011

Bioelectromagnetics

182

133

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New local treatments based on electromagnetic fields have been developed as non-surgical and minimally invasive treatments of tumors. In particular, short electric pulses can induce important non-thermal changes in cell physiology, especially the permeabilization of the cell membrane. The aim of this review is to summarize the present data on the electroporation-based techniques: electrochemotherapy (ECT), nanosecond pulsed electric fields (nsPEFs), and irreversible electroporation (IRE). ECT is a safe, easy, and efficient technique for the treatment of solid tumors that uses cell-permeabilizing electrical pulses to enhance the activity of a non-permeant (bleomycin) or low permeant (cisplatin) anticancer drug with a very high intrinsic cytotoxicity. The most interesting feature of ECT is its unique ability to selectively kill tumor cells without harming normal surrounding tissue. ECT is already used widely in the clinics in Europe. nsPEFs could represent a drug free, purely electrical cancer therapy. They allow the inhibition of tumor growth, and interestingly, nsPEF can target intracellular organelles. However, many questions remain on the mechanism of action of these pulses. Finally, IRE is a new ablation procedure using pulses that provoke the permanent permeabilization of the cells resulting in their death. This technique does not result in any thermal effect, which is its main advantage in current physical ablation technologies. For both the nsPEF and the IRE, the preservation of the normal tissue, which is characteristic of ECT, has not yet been shown and their safety and efficacy still have to be investigated thoroughly in vivo and in the clinics.

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Section: Bases Of Irreversible Electroporationmentioning

confidence: 99%

Microsecond and nanosecond electric pulses in cancer treatments

Breton¹,

Mir²

2011

Bioelectromagnetics

182

133

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“…Cyosurgical techniques have been used since the end of the 20th century with the availability of highresolution imaging techniques and new freezing equipment, and have been used to treat many types of tumors (Gage and Baust 2007;Mouraviev and Polascik 2006;. PC patients respond well to cryosurgery, with few surgical complications or deaths associated with this treatment (Kovach et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients

Zhou¹,

Niu²,

Chiu³

et al. 2012

Biotechnol Lett

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The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumor-supplied group of factors (TSGF) and tumor necrosis factor-α (TNF-α), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-α expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P < 0.05). One month after cryosurgery, serum levels of these markers were significantly reduced compared with levels prior to cryosurgery (P < 0.05), whereas there was no significant difference was found between serum levels before and after chemotherapy (P > 0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-α serum levels in these patients.

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“…The dreaded complication of urethrocutaneous fi stula is reported 1-2 % and is prevented by accurate temperature monitoring at denonvilliers fascia level. An excellent summary of key complications was published by Mourviev and Polascik [ 25 ].…”

Section: Complications Of Whole Gland Cryoablationmentioning

confidence: 99%

“…Impotence occurs largely due to the proximity of the neurovascular bundles to the cryogenic probes and modern systems attempt to prevent this by neurovascular bundle temperature monitoring. Traditionally, series have shown large range of impotence rates, anywhere from 4 to 88 %, with most in the 50-80 % [ 25 ]. Due to the possibility of sphincter involvement, most series show a 0.4-15 % rate of incontinence.…”

Section: Complications Of Whole Gland Cryoablationmentioning

confidence: 99%