Update on Chemical Peels

Landau, Marina; Bageorgeou, Fotini

doi:10.1016/j.det.2023.06.005

Cited by 1 publication

(3 citation statements)

References 43 publications

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“…Chemical peeling, or chemical exfoliation, involves applying acidic solutions like salicylic, lactic, and glycolic acids to the skin to promote exfoliation, depigmentation, and revitalization [ 119 ]. There are three levels of chemical peels: superficial, medium, and deep, chosen based on the extent of skin damage and patient expectations [ 120 ].…”

Section: Reviewmentioning

confidence: 99%

“…However, they may cause redness and peeling for up to two weeks post-treatment. Deep peels are aggressive treatments for severe wrinkles and scars [ 119 , 120 ]. In relation to the effects of chemical peeling on the hallmarks of skin aging, Kornhauser and colleagues [ 121 ] found that glycolic acid treatment, unlike salicylic acid, led to heightened sensitivity of human skin to solar simulated radiation.…”

Section: Reviewmentioning

confidence: 99%

“…This outcome was associated with DNA damage [ 121 ]. Given the importance of post-peeling care [ 119 ], it is recommended to conduct clinical tests on topical DNA repair enzymes. Intriguingly, in vitro research suggests that lactic acid may shield skin fibroblasts from aging-related mitochondrial dysfunction [ 122 ].…”

Section: Reviewmentioning

confidence: 99%

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Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

Minoretti,

Emanuele

2024

Cureus

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In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by the twelve traditional hallmarks of aging. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these hallmarks can be integrated with conventional aesthetic medicine techniques to enhance skin rejuvenation. The potential of combining targeted topical therapies against the aging hallmarks with minimally invasive procedures represents a significant advancement in aesthetic medicine, offering personalized and effective strategies to combat skin aging. The reviewed evidence paves the way for future advancements and underscores the transformative potential of integrating scientifically validated interventions targeted against aging hallmarks into traditional aesthetic practices.

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Section: Reviewmentioning

confidence: 99%