Update on caseous lymphadenitis in sheep

Gascoigne, Emily; Ogden, Nicky; Lovatt, Fiona; Davies, Peter N.

doi:10.1136/inp.m455

Cited by 9 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were supported by Pepin and Paton, who stated that the probability of developing internal lesions of CLA increased with age [8]. However, other studies have described the superficial form as the most prevalent in sheep [43] and also in goats [44]. In Iran, the authors found that 75.70% of the animals were affected by the cutaneous presentation and 24.30% by the visceral form [19].…”

Section: Discussionmentioning

confidence: 61%

“…Diagnostic imaging techniques, especially ultrasonography and computed tomography, can be very useful tools to diagnose the visceral form of the disease [39][40][41]. Furthermore, in order to eradicate the disease, ELISA test can be performed, although with a sensitivity of 87% and a specificity of 98% [42], prolonging the testing period, and extending time to eradication can occur, having consequences for the economic value of the flock [43].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Relevance of Caseous Lymphadenitis as a Cause of Culling in Adult Sheep

Ruíz

Ferrer

Ramos

et al. 2020

Animals

View full text Add to dashboard Cite

Four hundred and ninety-eight culled sheep received at the Ruminant Clinical Service of the Veterinary Faculty of Zaragoza, Spain, were examined in life and after humanitarian sacrifice in order to reach the final diagnosis of the cause of culling and to evaluate the presence of caseous lymphadenitis (CLA) lesions. One hundred and forty-seven of the 498 studied animals (29.52%) showed CLA compatible lesions that were subsequently confirmed by Corynebacterium pseudotuberculosis isolation. One hundred and seven of the 147 CLA affected animals presenting the visceral clinical form of the disease (72.79%), while only 32 animals were affected by the superficial form (21.77%). In addition, eight animals were found to be affected in both the visceral and the superficial presentations (5.44%). Eighty-four of the 147 CLA-affected animals (57.14%) did not show any concurrent disease, considering, in this case, CLA the main cause of culling (84/498: 16.87%). In the superficial presentation, the retropharyngeal lymph node, as a sole lesion, was the most frequently affected (13/32: 40.63%). Further, in the visceral form of the disease, 85.06% of the affected animals had the lesions located in the respiratory system (91/107: 85.06%). CLA was revealed as an important cause of culling in sheep production.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

The Relevance of Caseous Lymphadenitis as a Cause of Culling in Adult Sheep

Ruíz

Ferrer

Ramos

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…Various Corynebacterium phylotypes and have been identified in the sheep vaginal microbiota in previous studies (Swartz et al, 2014;Serrano et al, 2020), as well as in cultivation-based studies (Sawyer, 1977;Manes et al, 2018). Certain members within the Corynebacteriaceae family are known ovine pathogens, such as Corynebacterium pseudotuberculosis, which causes caseous lymphadenitis (Gascoigne et al, 2020). However, it is currently unknown if these OTUs, which showed higher abundance in nonpregnant animals than in pregnant animals, contribute to the negative outcome of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Ewe Vaginal Microbiota: Associations With Pregnancy Outcome and Changes During Gestation

et al. 2021

View full text Add to dashboard Cite

Reproductive performance is paramount to the success of livestock production enterprises focused on lamb meat production. Reproductive success is influenced by various factors, possibly including the reproductive tract microbial communities present at the time of copulation and throughout pregnancy. There are few publications that identify the vaginal microbial communities of livestock, and even fewer exist for sheep. To compare ewe vaginal microbial communities, vaginal swabs were taken from 67 Hampshire and Hampshire X Suffolk crossbred ewes from the Iowa State University sheep farm at a pre-breeding time point (S1) and after pregnancy testing (S2). Animals that were determined pregnant were sampled again within a few days of expected parturition (S3). DNA was extracted from these swabs, and 16S rRNA gene Illumina MiSeq amplicon sequencing was conducted to fingerprint the bacterial communities found within this system. Pre-breeding time point samples showed no differences in community structure between animals later found to be pregnant or non-pregnant, but significant changes were detected in species richness (Chao; P < 0.001) and species diversity (Shannon; P < 0.001) at the second sampling time point. A higher microbial diversity within the S2 time point samples may suggest a more stable environment driven by pregnancy, as this increased diversity is maintained in pregnant animals from the S2 to the S3 time point. Additionally, several bacterial phylotypes, such as Mannheimia, Oscillospiraceae-like OTUs and Alistipes, were more abundant at either the S1 or S2 time points in animals that established pregnancy, suggesting a beneficial effect on pregnancy outcome. This study identifies changes within the microbial communities of the ewe vagina before and during gestation and offers inferences on how these changes may impact pregnancy outcome. Information presented herein offers new knowledge about sheep vaginal microbial communities and serves as a starting point to help guide researchers to improve sheep reproductive performance in the future.

show abstract

“…This review highlights the broad variety of toxic organic/inorganic compounds and plants that may be involved in states of emaciation, wasting, and loss of productivity in sheep. These conditions should be thus considered as differential diagnoses, especially in those animals and flocks where the classic infectious and parasitic wasting diseases have been ruled out [ 1 , 2 , 3 , 4 ]. Diagnosis may be fastidious in many cases, since lesions could be minimal and/or unspecific, and a good anamnesis focused on revealing a history of exposure should be the cornerstone of the diagnostic work-up.…”

Section: Discussionmentioning

confidence: 99%

“…There are several diseases of sheep that may cause wasting, leading to decreased productivity and economic losses in sheep flocks as a result. Johne’s disease, maedi-visna, caseous lymphadenitis, and several parasitic diseases, amongst others, have been traditionally included under the umbrella of the so-called “thin ewe syndrome”, a concept that encompasses several diseases with wasting as the main clinical sign [ 1 , 2 , 3 , 4 ]. Hence, this concept has included mostly infectious and parasitic disorders, probably underestimating the role of other disease causes.…”

Section: Introductionmentioning

confidence: 99%

Toxic Wasting Disorders in Sheep

Molín

Mendonça

Henderson

et al. 2021

Animals

View full text Add to dashboard Cite

Infectious and parasitic agents have been frequently associated with debilitating and wasting conditions in sheep. The prevalence of these agents has probably undermined the role of toxic causes as contributors to such disorders. In addition, many of these intoxications frequently produce acute clinical disease with specific and characteristic lesions, thus a causal relationship with the toxic substance may be relatively easy to establish. However, persistent exposure to some of these organic or inorganic toxic substances may lead to emaciation, ill-thrift, and poor external aspect. The anti-nutritional factors and alkaloids of several plants, including pyrrolizidine alkaloids, among others, have also been associated with emaciation and/or poor general performance in sheep flocks. In this review, some of these disorders are discussed with an emphasis on clinical signs and lesions, relevant diagnostic aspects, and available therapeutic approaches. In most cases, demonstrating a history of exposure should be one of the most relevant aspects of the diagnostic approach, and removing the animals from the toxic source is the cornerstone of the majority of the treatment strategies.

show abstract

Update on caseous lymphadenitis in sheep

Cited by 9 publications

References 29 publications

The Relevance of Caseous Lymphadenitis as a Cause of Culling in Adult Sheep

The Relevance of Caseous Lymphadenitis as a Cause of Culling in Adult Sheep

Ewe Vaginal Microbiota: Associations With Pregnancy Outcome and Changes During Gestation

Toxic Wasting Disorders in Sheep

Contact Info

Product

Resources

About