Update on Barrett’s esophagus diagnosis and treatment

Кайбышева, В. О.; Kashin, Sergey; Karasev, A V; Merkulova, A. O.; Krainova, E. A.; Fedorov, Evgeny; Shapoval'yants, S. G.

doi:10.17116/dokgastro2020904133

Cited by 2 publications

(1 citation statement)

References 85 publications

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“…Абдоминальное ожирение, вне зависимости от ИМТ, ассоциировано с повышенным риском развития ПБ (1,4 раз) (суммарное ОШ 1,98, 95% ДИ 1,52-2,57) и АКП (4,76 раз) (суммарное ОШ 2,51, 95% ДИ 1,54-4,06) [39,40,41].…”

Section: взаимосвязь гэрб и компонентов мс ожирениеunclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

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Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.

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Section: взаимосвязь гэрб и компонентов мс ожирениеunclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

View full text Add to dashboard Cite

show abstract

Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors

Маев

Bordin

Barkalova

et al. 2023

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Аim: to identify predictors of insufficient effectiveness of proton pump inhibitors based on the evaluation of the results of 24-hour pH-impedance and high-resolution esophageal manometry in patients with Barrett's esophagus.Materials and methods. 52 patients with histologically confirmed Barrett's esophagus who are on therapy with proton pump inhibitors were examined. All patients underwent daily pH-impedance and high-resolution esophageal manometry.Results. According to daily pH-impedance, group 1 consisted of 37 patients who responded satisfactorily to antisecretory therapy, group 2 of 15 patients who demonstrated insufficient response to acid-suppressive therapy, 11 of whom had no clinical manifestations. The total number of reflux averaged 55 in group 1 and 106 in group 2. The average number of acid reflux in group 1 was 5.68, in group 2 — 48.5. The average number of non-acid reflux prevailed in patients of group 2 and averaged 58, in group 1 the indicator averaged 47. Evaluation of the results of high-resolution esophageal manometry showed that violations of the structure and function of the esophago-gastric junction were detected in 21 patients out of 52. Disorders of the motility of the thoracic esophagus were detected in 31 patients out of 52. When comparing the frequency of motor disorders from the thoracic esophagus in groups 1 and 2, no significant differences were obtained. However, significantly more frequent registration of violations of the structure and/or function of the esophago-gastric junction was found in the group with unsatisfactory effectiveness of proton pump inhibitors.Conclusion. In a number of patients with Barrett's esophagus, there is an insufficient effect of acid-suppressive therapy and at the same time an asymptomatic course of the disease, which may increase the risk of its progression. Predictors of insufficiently successful treatment of patients with Barrett's esophagus may be both insufficient pharmacological effect of proton pump inhibitors themselves, and motility disorders that cause the presence of non-acid reflux, decreased esophageal clearance, which in turn may cause the patient's symptoms to persist and adversely affect the condition of the esophageal mucosa.

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Update on Barrett’s esophagus diagnosis and treatment

Cited by 2 publications

References 85 publications

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors

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