Update on amniotic membrane transplantation

Liu, Jingbo; Sheha, Hosam; Fu, Yao; Liang, Lingyi; Tseng, Scheffer C.G.

doi:10.1586/eop.10.63

Cited by 158 publications

(125 citation statements)

References 161 publications

(154 reference statements)

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“…Why these mechanisms are downregulated or turned off in fetal membranes remains to be determined. Interestingly, amniotic membrane has been used to promote healing in clinical situations such as corneal burning and ulcerations, dural defects, intra-abdominal adhesions, peritoneal and genital reconstruction, hip arthroplasty, tendon and nerve repair, microvascular, oral and nasal reconstructive surgical procedures (24,25). Both fresh and processed amniotic membranes appear to hold a variety of regulatory mediators that promote cellular proliferation, differentiation, and epithelialization (26,27).…”

Section: Articlesmentioning

confidence: 99%

Histologic changes of the fetal membranes after fetoscopic laser surgery for twin-twin transfusion syndrome

et al. 2015

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Background: Preterm premature rupture of membranes remains a major complication after fetoscopic laser surgery (FLS) for twin-twin transfusion syndrome (TTTS). We studied the histologic changes of fetal membranes post-FLS and investigated a possible impact of amniotic fluid (AF) dilution. Methods: Fetal membranes of 31 pregnancies that underwent FLS for TTTS were investigated histologically at delivery at different sites: trocar site of recipient sac and at distance, donor sac, and inter-twin membrane. results: The trocar insertion site on the recipient sac showed no signs of histologic hallmarks of healing. Wide-spread alteration in collagen organization and higher apoptotic index in the amnion of the recipient sac which were absent in donor's and reference membranes. To explain the mechanisms, we analyzed the AF composition of recipient sacs from TTTS pregnancies vs. GA-matched healthy singleton controls and found glucose, protein and lactate dehydrogenase activity were all significantly lower in TTTS sacs consistent with over-dilution of recipient's AF (~2-fold). In-vitro exposure of healthy amniochorion to analogous dilutional stress conditions recapitulated the histologic changes and induced apoptosis and autophagy. conclusion: Alteration in structural integrity of the recipient's amniochorion, possibly in response to dilution stress, along with ineffective repair mechanisms may explain the increased incidence of preterm birth post-FLS.d espite the success of fetoscopic laser surgery (FLS) for the treatment of severe twin-twin transfusion (TTTS), preterm delivery with or without preterm premature rupture of membranes (PPROM) remains a major complication (1-4). The average gestational age at delivery after procedure ranges between 29 to 33 wk (1,5). Aside from the cost of caring for the premature infants, preterm delivery is directly associated with long-term neurological deficits in TTTS (4,6), undermining the complete benefits of such intervention. PPROM which affects 20-32% of cases is the most important risk factor leading to preterm delivery (2,7-10).Considered a minimally invasive procedure, FLS necessitates the insertion of a trocar into the amniotic cavity of the recipient twin to allow for insertion of the fetoscope (through a cannula which stays in place throughout the procedure) (11). A laser is used to seal the abnormal blood vessel anastomoses between the monochorionic twin placentas. Lastly, the surgeon performs an amnioreduction to relieve the recipient's polyhydramnios by draining the excess amniotic fluid (AF) through the cannula before removing it. During the procedure to allow proper visualization due to the inadvertent loss of amniotic fluid through cannula port or due to cloudy AF, it is customary for the surgeon to remove a volume of AF and replace it via amnioinfusion with a solution of Lactated Ringer's (LR).Fetal membranes are the outermost layer of fetal compartment in apposition to maternal decidua. The amniotic layer of the fetal membranes is made up of a lining of cuboidal epithe...

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Section: Articlesmentioning

confidence: 99%

Histologic changes of the fetal membranes after fetoscopic laser surgery for twin-twin transfusion syndrome

et al. 2015

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“…The AM is located between the maternal uterus and the fetus. The AM completely surrounds the fetus, and is composed of a fused inner fetal layer, the amnion, and an outer uterine layer, the chorion [3,4]. These membranes are derived from cells of the developing fetus and play a key role in fetal development.…”

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confidence: 99%

“…The AM has been shown to have anti-inflammatory effects and to promote epithelialization [3,4]. These properties have led to its use in diverse surgical settings, including ophthalmology and wound care [3][4][5][6][7][8][9][10].…”

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confidence: 99%

“…These properties have led to its use in diverse surgical settings, including ophthalmology and wound care [3][4][5][6][7][8][9][10]. Based on anecdotal experience and extensive literature supporting the anti-inflammatory and epithelialization-promoting properties of AM, we hypothesized that the use of autologous AM during in utero MMC repair would provide improved protection to the spinal cord.…”

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confidence: 99%

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In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model

Brown

Saadai

Pivetti

et al. 2014

Journal of Pediatric Surgery

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“…It has been shown to aid reepithelialization and reduce inflammation and scarring. [50] The more complex nature of the conjunctival epithelium than the corneal epithelium adds extra considerations when designing a substrate to facilitate its expansion for transplantation. The substrate needs to support both epithelial cells and goblet cell growth and promote the secretion of mucins from the goblet cells.…”

Section: Conjunctiva Damage and Repairmentioning

confidence: 99%

Biomaterials for Regenerative Medicine Approaches for the Anterior Segment of the Eye

Williams

Lace

Kennedy

et al. 2018

Adv Healthcare Materials

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The role of biomaterials in tissue engineering and regenerative medicine strategies to treat vision loss associated with damage to tissues in the anterior segment of the eye has been studied for several years. This has mostly involved replacement and support for the cornea and conjunctiva. These are complex tissues with specific functional requirements for different parts of the tissue. Amniotic membrane (AM) is used in clinical practice to transplant autologous or allogenic cells to the corneal surface. Fibrin gels have also progressed to clinical use under specific conditions. Alternatives to AM such as collagen gels, other natural materials, for example keratin and silks, and synthetic polymers have received considerable attention in laboratory and animal studies. This experience is building a body of evidence to demonstrate the potential of tissue engineering and regenerative medicine in corneal and conjunctival reconstruction and can also lead to other applications in the anterior segment of the eye, for example, the trabecular meshwork. There is a real clinical need for new procedures to overcome vision loss but there are also opportunities for developments in ocular applications to lead to biomaterials innovations for use in other clinical areas.

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Update on amniotic membrane transplantation

Cited by 158 publications

References 161 publications

Histologic changes of the fetal membranes after fetoscopic laser surgery for twin-twin transfusion syndrome

Histologic changes of the fetal membranes after fetoscopic laser surgery for twin-twin transfusion syndrome

In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model

Biomaterials for Regenerative Medicine Approaches for the Anterior Segment of the Eye

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