Update on active specific immunotherapy with melanoma vaccines

Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complex

“…Immunization techniques against tumor antigens have been successful in protecting animals against the subsequent growth of tumors that express the same antigens, findings which support the immunosurveillance theory that was originally proposed by Thomas (21) and Burnet (22). Vaccination pro- cedures based on this information are currently undergoing clinical trials for selected human malignancies (23,24).…”

Malignant melanoma: prevention, early detection, and treatment in the 21st century

“…The hypothesis that such regression may be associated with vitiligo provides a rational basis for melanocyte antigen‐directed immunotherapy 108 . Successful active specific immunotherapy would provide a host with tumor antigen in the correct context to allow generation of an immune response 109,110 …”

Oral metronomic cyclophosphamide in elderly with metastatic melanoma

“…Besides, several immunological modifications have been described with the metronomic cyclophosphamide [24,[30][31][32][33] as summarized in Table 3. Immunomodulation is interesting in immunodepressed patients [13,34,35] with immunogenic cancer [30].…”

“…Immunomodulation is interesting in immunodepressed patients [13,34,35] with immunogenic cancer [30]. Decrease of interleukin 10 and TGF beta [30] Associating immunomodulation and antiangiogenic action may explain the disease's stabilisation.…”