Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection — United States, February 2016

Fleming-Dutra, Katherine E.; Fischer, Marc; Staples, J. Erin; Karwowski, Mateusz P.; Mead, Paul S.; Villanueva, Julie; Renquist, Christina M.; Minta, Anna A.; Jamieson, Denise J.; Honein, Margaret A.; Moore, Cynthia A.; Rasmussen, Sonja A.

doi:10.15585/mmwr.mm6507e1

Cited by 73 publications

(68 citation statements)

References 23 publications

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“…To date, microcephaly has not been reported in any child who was infected with ZIKV at the time of birth [70]. The signs and symptoms of the disease in children are similar to those of infected adults [11,69]; however, arthralgia is sometimes difficult to detect in children and can manifest as irritability, pain on palpation, walking with a limp, refusal to move or movement with great difficulty, or feeling pain while moving the affected joint [69]. No growth-related abnormalities have been reported in children who were born healthy and later developed ZIKV disease.…”

Section: Childrenmentioning

confidence: 97%

“…Two different case reports described intrapartum transmission of ZIKV to infants and newborns, who developed infection within a few weeks of delivery. One newborn had no clinical signs or symptoms, whereas the other presented with diffuse rash and thrombocytopenia [52,69]. To date, microcephaly has not been reported in any child who was infected with ZIKV at the time of birth [70].…”

Section: Childrenmentioning

confidence: 99%

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Zika virus disease: a current review of the literature

et al. 2016

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Section: Childrenmentioning

confidence: 97%

Section: Childrenmentioning

confidence: 99%

Zika virus disease: a current review of the literature

et al. 2016

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“…The majority of children, who are infected with ZIKV through mosquito bites, remain asymptomatic or have a mild disease, similar to ZIKV-infected adults (26). These children become infected through 3 routes: vertical transmission during pregnancy (intrauterine), transmission in the perinatal period (intrapartum), and mosquito bites (postpartum infection) (26).…”

Section: Infection and Disease In Healthy Subjectsmentioning

confidence: 99%

“…However, the literature search indicated 2 cases of death in a 15-year-old girl with sickle-cell anemia and a 16-year-old female with signs such as headache, nausea, and petechiae. In general, clinical symptoms of ZIKV infection include headache, fever, chills, pharyngitis, lymphadenopathy, maculopapular rash, joint and muscle pain, and nonpurulent conjunctivitis (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32).…”

Section: Infection and Disease In Healthy Subjectsmentioning

confidence: 99%

“…Based on previous reports, children with acute ZIKV infection (onset of symptoms within the past 7 days) should be assessed by RT-PCR assay. If ZIKV RNA is not distinguished and the signs are present for more than 4 days, the serum can be used for Zika virus IgM (and neutralizing antibodies), as well as Dengue virus IgM (and neutralizing antibodies) (26).…”

Section: Diagnosismentioning

confidence: 99%

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Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

Karimi

Razavi

2017

J Pediatr Rev

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Context: Zika virus (ZIKV) is an arbovirus of the family Flaviviridae. This virus, which is transmitted by mosquitoes, usually affects children and causes self-limited diseases, associated with fever, maculopapular rash, conjunctivitis, arthralgia, and myalgia. There is a significant relationship between ZIKV infection and central nervous system disorders in infants. In this study, we aimed to review neurologic manifestations of ZIKV infection in infants. Evidence Acquisition: We searched the following Mesh terms in scientific databases: "Zika virus", "infants", "children", "neurologic manifestations", and "congenital infection". Electronic databases including Google Scholar, Science Direct, PubMed, Web of Science, Scientific Information Database, and Scopus were searched from 2000 to 2016. Results:The literature review showed a probable relationship between ZIKV infection and prevalence of microcephaly in newborns. Besides microcephaly, other central nervous system abnormalities included abnormal gyral arrangement, decreased brain parenchymal volume, cortical atrophy and malformation, cerebellar hypoplasia, and delayed myelination of the brain stem. Conclusions: Vertical transmission of ZIKV in pregnant women is associated with intrauterine infection and brain malformations in the developing fetus, including microcephaly, calcification, cortical displacement, ventriculomegaly, and white-matter abnormalities.

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Developmental Outcomes Among Young Children With Congenital Zika Syndrome in Brazil

et al. 2020

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IMPORTANCE Although birth defects in children with congenital Zika syndrome (CZS) are expected to result in significant intellectual disabilities, the extent of delay and profiles of development have yet to be fully described. OBJECTIVES To describe the neurodevelopmental profiles of children with CZS and to test whether prenatal and postpartum characteristics were associated with the severity of developmental delays. DESIGN, SETTING, AND PARTICIPANTS This is a case series of the trajectories of developmental, behavioral, and medical needs of 121 young children with CZS who were assessed at a specialized rehabilitation center in Recife, Brazil, beginning in January 2018 as part of 5-year longitudinal study. Children were included if they had serologic confirmation of Zika virus and met clinical criteria accompanied by parental report of suspected exposure to Zika virus during pregnancy. EXPOSURES Prenatal Zika virus exposure. MAIN OUTCOMES AND MEASURES The Brazilian version of the Bayley Scales of Infant and Toddler Development, Third Edition, was administered by trained assessors as part of an initial comprehensive assessment battery. Caregiver interviews and medical record reviews were conducted to gather basic demographic information and medical comorbidities. Linear regression was used to identify potential factors for development. RESULTS The sample included 121 young children (mean [SD] age, 31.2 [1.9] months; 61 [50.4%] girls). At age approximately 2.5 years, nearly all children in this sample demonstrated profound developmental delays across all domains of functioning, with a mean (SD) developmental age equivalent to approximately 2 to 4 months (eg, cognitive domain, 2.24 [3.09] months; fine motor subscale, 2.15 [2.93] months; expressive language subscale, 2.30 [2.52] months). A relative strength was found in receptive language, with scores on this scale significantly higher than most other domains

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Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection — United States, February 2016

Cited by 73 publications

References 23 publications

Zika virus disease: a current review of the literature

Zika virus disease: a current review of the literature

Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

Developmental Outcomes Among Young Children With Congenital Zika Syndrome in Brazil

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