Update in Thyroid Fine Needle Aspiration

Faquin, William C.; Bongiovanni, Massimo; Sadow, Peter M.

doi:10.1007/s12022-011-9182-7

Cited by 21 publications

(21 citation statements)

References 41 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thyroid fine-needle aspiration (FNA) is still among the most commonly performed procedures to evaluate thyroid parenchymal nodules (1). Beside clinically evident and palpable thyroid nodules that are present in up to 7% of the general population, ultrasonographic evaluation of the neck performed in various clinical settings bring to light up to 70% of non-palpable and deep-seated nodules (2,3,4).…”

Section: Introductionmentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: High-yield thyroid fine-needle aspiration cytology: an update focused on ancillary techniques improving its accuracy

Bongiovanni

Trimboli

Rossi

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

Thyroid fine-needle aspiration (FNA) cytology is a fast growing field. One of the most developing areas is represented by molecular tests applied to cytological material. Patients that could benefit the most from these tests are those that have been diagnosed as 'indeterminate' on FNA. They could be better stratified in terms of malignancy risk and thus oriented with more confidence to the appropriate management. Taking in to consideration the need to improve and keep high the yield of thyroid FNA, professionals from various fields (i.e. molecular biologists, endocrinologists, nuclear medicine physicians and radiologists) are refining and fine-tuning their diagnostic instruments. In particular, all these developments aim at increasing the negative predictive value of FNA to improve the selection of patients for diagnostic surgery. These advances involve terminology, the application of next-generation sequencing to thyroid FNA, the use of immunocyto-and histo-chemistry, the development of new sampling techniques and the increasing use of nuclear medicine as well as molecular imaging in the management of patients with a thyroid nodule. Herein, we review the recent advances in thyroid FNA cytology that could be of interest to the 'thyroid-care' community, with particular focus on the indeterminate diagnostic category.

show abstract

Section: Introductionmentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: High-yield thyroid fine-needle aspiration cytology: an update focused on ancillary techniques improving its accuracy

Bongiovanni

Trimboli

Rossi

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Among these, papillary thyroid carcinoma (PTC) is the most frequent histologic type, comprising 70% to 85% of all thyroid malignancies . Over the past 3 decades, fine‐needle aspiration biopsy (FNAB) has developed as the most effective method for evaluation and triage of patients with thyroid nodules, partially explaining the increased incidence of thyroid cancer during that period . The ability to accurately diagnose PTC by FNAB is essential because it has major implications for subsequent patient management .…”

Section: Introductionmentioning

confidence: 99%

CD117: A novel ancillary marker for papillary thyroid carcinoma in fine‐needle aspiration biopsies

Pusztaszeri

Sadow

Faquin

2014

Cancer Cytopathology

Self Cite

View full text Add to dashboard Cite

BACKGROUND: c-KIT/CD117 down-regulation has been described in papillary thyroid carcinoma (PTC). In this study, the authors investigated CD117 as an ancillary immunocytochemical test for PTC in fine-needle aspiration biopsy (FNAB). METHODS:The expression of CD117 was assessed in cytologic samples of histologically confirmed classic PTC (n 5 35) and in a control group of benign thyroid nodules (BTNs) (n 5 30) using immunocytochemistry. The corresponding PTCs and BTNs from surgical resection specimens also were evaluated immunohistochemically for CD117. The expression of CD117 was assessed semiquantitatively using a scoring system from 0 to 5 that combined the proportion and the intensity of staining. RESULTS: The difference in immunoreactivity for CD117 between PTC and BTNs was highly significant both in FNAB samples and in the corresponding histology samples (P <.0001). On cytology, most PTCs (74%; n 5 26) lacked immunoreactivity for CD117, and 9 samples (26%) had faint reactivity in <2% of tumor cells (score, 0). In contrast, all BTNs (100%; n 5 30) were positive for CD117, and at least 50% of the cells (score, 2-4) were positive in 79% (n 5 24) of BTNs.Results with corresponding histology were similar to the cytology results; most PTCs (89%; n 5 31) lacked immunoreactivity for CD117, and 4 samples (11%) had faint reactivity in <2% of tumor cells. In contrast, all BTNs (n 5 30) were variably positive for CD117 (score, 2-4). Normal follicular epithelium also was positive for CD117 (score, 2-4). CONCLUSIONS: CD117 is expressed in both normal follicular epithelium and in BTNs. In contrast, expression of CD117 is absent or weak in PTC.These results suggest that CD117 may be useful as an ancillary marker for PTC. Cancer (Cancer Cytopathol) 2014;122:596-603.

show abstract

“…This implies a national rate for the UK as a whole of around 500 FNAs per million. In the USA Faquin et al 13 state that 350 000 thyroid FNAs are performed per year, implying a rate of approximately 1100 per million population. Thyroid FNA is therefore a commonly performed procedure.…”

Section: Methodsmentioning

confidence: 99%

A simplified economic approach to thyroid FNA cytology and surgical intervention in thyroid nodules

Poller

Kandaswamy

2013

J Clin Pathol

View full text Add to dashboard Cite

show abstract

Update in Thyroid Fine Needle Aspiration

Cited by 21 publications

References 41 publications

DIAGNOSIS OF ENDOCRINE DISEASE: High-yield thyroid fine-needle aspiration cytology: an update focused on ancillary techniques improving its accuracy

DIAGNOSIS OF ENDOCRINE DISEASE: High-yield thyroid fine-needle aspiration cytology: an update focused on ancillary techniques improving its accuracy

CD117: A novel ancillary marker for papillary thyroid carcinoma in fine‐needle aspiration biopsies

A simplified economic approach to thyroid FNA cytology and surgical intervention in thyroid nodules

Contact Info

Product

Resources

About