Update in diagnosis and management of interstitial lung disease

Mikolasch, Theresia; Garthwaite, Helen; Porter, Joanna C.

doi:10.7861/clinmedicine.17-2-146

Cited by 66 publications

(60 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of clinical research of Cantabria, Spain (2016.092). A diagnosis of ILD was made by the pneumologists based on clinical and radiological findings and pulmonary function test abnormalities following the clinical guidelines [1,22]. A definitive histological confirmation by transbronchial biopsy, surgical lung biopsy (including lung explants biopsy) or cryobiopsy was performed by experienced pathologists according to the pneumologist consideration.…”

Section: Patientsmentioning

confidence: 99%

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Atienza‐Mateo

Remuzgo‐Martínez

Cuesta

et al. 2020

JCM

View full text Add to dashboard Cite

Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associated with AD (AD-ILD) among patients sent for assessment to a single clinic of ILD and lung transplantation from a referral center between May 2016 and December 2019. ILD diagnosis was made by pneumologists based on clinical and radiological findings and pulmonary function test abnormalities. All patients with ILD were also assessed by experienced rheumatologists. During the period of assessment, 338 patients were diagnosed with ILD. Among them, 32.8% fulfilled definitions for an AD. Most cases with AD-ILD had a diagnosis of rheumatoid arthritis (27.0%), systemic sclerosis (26.1%) or anti-synthetase syndrome (17.1%). Interestingly, 18% of the patients with AD-ILD were diagnosed as having an interstitial pneumonia with autoimmune features. Antinuclear antibodies and non-specific interstitial pneumonia were the most frequent positive autoantibodies and radiological pattern found in AD-ILD patients, respectively. In conclusion, our study indicates that a high number of ILD patients have a related AD. Consequently, close collaboration among rheumatologists and pneumologists is needed.

show abstract

Section: Patientsmentioning

confidence: 99%

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Atienza‐Mateo

Remuzgo‐Martínez

Cuesta

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…This is then supported by physiological testing and laboratory findings, 8,11 including screening for autoantibodies, immunoglobulins against organic antigens and serum angiotensin-converting enzyme and pulmonary function tests. 1 Where an identifiable cause for ILD cannot be found, specific combinations of patterns on CT and surgical lung biopsy, where indicated, can then lead to the diagnosis of IPF. 8,11 The extent to which we can conclusively exclude other triggers or diseases that can lead to end stage PF in cats, due to practical constraints such as exposure to unknown environments or unknown previous history, limits the confidence in diagnosing true IPF in cats.…”

Section: Discussionmentioning

confidence: 99%

“…The latter are termed idiopathic interstitial pneumonias (IIP) and include idiopathic pulmonary fibrosis (IPF). 1,2 A similar, modified classification for ILD has been proposed for dogs and cats. 3…”

Section: Introductionmentioning

confidence: 99%

Clinical, computed tomographic and histopathological findings in two cats with pulmonary fibrosis of unknown aetiology

Duffy

Griffin

O’Connell

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

View full text Add to dashboard Cite

Case series summary Two cats were presented for further investigation of respiratory signs. One cat had a history of a cough and the other, tachypnoea. In each case, thoracic CT was performed, which revealed a generalised marked reticular pattern in the first cat and focal consolidation of the right caudal lung lobe in the second cat. The first cat was euthanased following completion of the imaging study and a post-mortem examination was performed. The second cat underwent surgical excision of the abnormal lung lobe and survived for 4 years after diagnosis. Histopathology performed on lung tissue removed from each cat was consistent with pulmonary fibrosis. Relevance and novel information This small case series adds to the existing literature and highlights the heterogeneous clinical course and variable appearance of pulmonary fibrosis on CT of affected cats. These cases provide evidence that pulmonary fibrosis in cats incorporates a wide spectrum of fibrotic lung disease and demonstrates the possibility for prolonged survival following diagnosis where disease is localised and amenable to surgical resection.

show abstract

“…Interstitial lung disease (ILD) was defined by the following inclusion criteria: 1) Radiological evidence of ILD on HRCT (such as reticular abnormality or honeycombing with or without traction bronchiectasis), and/or lung function testing consistent with ILD. 2) The exclusion of another possible aetiological factor (such as drugs and dust) in the development of ILD [28].…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics and outcomes in microscopic polyangiitis patients with renal involvement: a study of 124 Chinese patients

Shi

Shen

2019

BMC Nephrol

View full text Add to dashboard Cite

Background Microscopic polyangiitis (MPA) is a systemic autoimmune disease, and renal involvement is frequently present in MPA. MPA patients with renal involvement may have a worse prognosis. In this study, we aimed to evaluate the prognostic factors associated with all-cause death and renal survival in MPA patients with renal involvement. Methods A retrospective observational cohort study was performed. One hundred twenty-four patients newly diagnosed with MPA with renal involvement excluding end-stage renal disease (ESRD) who were hospitalized at the First Affiliated Hospital of Chongqing Medical University from January 2012 to July 2017 were included. All the survivors were followed up with until July 2018. The clinical and laboratory data at the time of the initial MPA diagnosis were collected, and the predictive values of the variables for mortality and renal outcome were analysed. Results Among the 124 patients, 52 were men (41.9%) and 72 were women (58.1%), and the age range was from 25 to 85 years (63.9±10.6 years). Seventy-six patients (61.3%) had pulmonary involvement. Multivariate Cox analysis revealed that age≥65 years (HR: 2.437; P =0.021), serum creatinine≥500 μmol/L (HR=2.207; P =0.009) and interstitial lung disease (ILD) (HR=2.366; P =0.013) were associated with mortality. Cox multivariate analysis identified that serum creatinine≥500 μmol/L (HR=8.236; P <0.001) and ILD (HR=2.649; P =0.001) were independent detrimental factors for renal survival, and immunosuppressive treatment was a protective factor for renal survival (HR=0.349; P =0.001). The area under the ROC curve (AUC) of the serum creatinine level at diagnosis was 0.705 for mortality and 0.870 for progression to ESRD or the doubling of serum creatinine. Conclusions Age, serum creatinine level at diagnosis and ILD were independent predictors of mortality in MPA patients with renal involvement. Serum creatinine level at diagnosis, ILD and immunosuppressive treatment were independently related to renal survival.

show abstract

Update in diagnosis and management of interstitial lung disease

Cited by 66 publications

References 26 publications

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Clinical, computed tomographic and histopathological findings in two cats with pulmonary fibrosis of unknown aetiology

Clinical characteristics and outcomes in microscopic polyangiitis patients with renal involvement: a study of 124 Chinese patients

Contact Info

Product

Resources

About