Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium

Rello, Jordi; Belliato, Mirko; Dimopoulos, Meletios A.; Giamarellos‐Bourboulis, Evangelos J.; Jaksic, Vladimir; Martín‐Loeches, Ignacio; Mporas, Iosif; Pelosi, Paolo; Poulakou, Garyfallia; Pournaras, Spyridon; Kakazu, Maximiliano Tamae; Timsit, Jean François; Waterer, Grant; Tejada, Sofía; Dimοpoulos, George

doi:10.1016/j.accpm.2020.10.008

Cited by 33 publications

(31 citation statements)

References 67 publications

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“…Those requiring higher levels of medical input for COVID-19 related illness will be more likely to develop psychiatric conditions requiring treatment, as observed following the 2009 H1N1 pandemic [ 14 ]. Estimates of total numbers of patients requiring critical care vary markedly, but of confirmed cases of COVID-19, however, 15% will require hospitalisation and 5% will require invasive mechanical ventilation on an Intensive Therapy Unit [ 15 ]. The prevalence of PTSD symptoms following ITU discharge is 24% at 6 months and 22% at 12 months [ 16 , 17 ], comparable to that of military combat and major physical injury [ 18 ].…”

Section: At Risk Population Groupsmentioning

confidence: 99%

Managing COVID-19 related distress in primary care: principles of assessment and management

et al. 2021

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COVID-19 will cause normal feelings of worry and stress and many of those who experience higher levels of distress will experience resolution of their symptoms as society returns to pre-COVID-19 functioning. Only a minority are likely to develop a psychiatric disorder. Certain individuals may be vulnerable to experiencing persisting symptoms, such as those with pre-existing comorbidity. Management approaches could centre around using collaborative approaches to provide and build on already existing socioeconomic support structures, the avoidance of over-medicalisation, watchful waiting and finally treating those who do meet the criteria for psychiatric diagnosis. Primary care clinicians are likely be the first healthcare point of contact for most COVID-19 related distress and it is important that they are able to provide evidence based and evidence informed responses, which includes social, psychological and pharmacological approaches. This expert opinion paper serves to summarise some approaches, based primarily on indirect extrapolation of evidence concerning the general management of psychological distress, in the absence of COVID-19 specific evidence, to assist primary care clinicians in their assessment and management of COVID-19 related distress.

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Section: At Risk Population Groupsmentioning

confidence: 99%

Managing COVID-19 related distress in primary care: principles of assessment and management

et al. 2021

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“…Cultures including blood, sputum, and bronchoalveolar samples should be obtained as soon as possible, together with a routine HIV test, pneumococcal and Legionella urinary antigen testing before starting empirical antibiotic therapy, and when the decision to start antibiotic therapy is made, the treatment should be based on the clinical severity and according to local and/or national guidelines [ 64 , 65 ]. Antibiotic treatment should last 5 days in patients with COVID-19 and/or until improvement of clinical, radiologic and laboratory findings [ 66 ].…”

Section: Introductionmentioning

confidence: 99%

Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19

Robba

Battaglini

Ball

et al. 2021

Expert Review of Respiratory Medicine

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Introduction: The ongoing pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed important challenges for clinicians and health-care systems worldwide. Areas covered: The aim of this manuscript is to provide brief guidance for intensive care unit management of mechanically ventilated patients with COVID-19 based on the literature and our direct experience with this population. PubMed, EBSCO, and the Cochrane Library were searched up until 15th of January 2021 for relevant literature. Expert opinion: Initially, the respiratory management of COVID-19 relied on the general therapeutic principles for acute respiratory distress syndrome; however, recent findings have suggested that the pathophysiology of hypoxemia in patients with COVID-19 presents specific features and changes over time. Several therapies, including antiviral and anti-inflammatory agents, have been proposed recently. The optimal intensive care unit management of patients with COVID-19 remains unclear; therefore, ongoing and future clinical trials are warranted to clarify the optimal strategies to adopt in this cohort of patients.

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“…After entry, the virus can multiply and disseminate into the airway after shutting down IFN type 1 antiviral pathway. The virus generally spreads from the lung and can also disseminate to other ACE2 expressing tissues (6). It is widely known that ACE2 is highly abundant on alveolar pneumocytes, enabling SARS-CoV-2 to enter and infect these cells.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

The COVID-19 infection in children and its association with the immune system, prenatal stress, and neurological complications

Khan¹,

Siddique²,

Hao³

et al. 2022

Int. J. Biol. Sci.

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The Coronavirus disease 2019 (COVID-19)" caused by the "severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)" has caused huge losses to the world due to the unavailability of effective treatment options. It is now a serious threat to humans as it causes severe respiratory disease, neurological complications, and other associated problems. Although COVID-19 generally causes mild and recoverable symptoms in children, it can cause serious severe symptoms and death causing complications. Most importantly, SARS-CoV-2 can cause neurological complications in children, such as shortness of breath, myalgia, stroke, and encephalopathy. These problems are highly linked with cytokine storm and proinflammatory responses, which can alter the physiology of the blood-brain barrier and allow the virus to enter the brain. Despite the direct infection caused by the virus entry into the brain, these neurological complications can result from indirect means such as severe immune responses. This review discusses viral transmission, transport to the brain, the associated prenatal stress, and neurological and/or immunological complications in children.

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Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium

Cited by 33 publications

References 67 publications

Managing COVID-19 related distress in primary care: principles of assessment and management

Managing COVID-19 related distress in primary care: principles of assessment and management

Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19

The COVID-19 infection in children and its association with the immune system, prenatal stress, and neurological complications

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