Update in Chronic Obstructive Pulmonary Disease 2011

Agustí, Àlvar; Barnes, Peter J.

doi:10.1164/rccm.201203-0505up

Cited by 22 publications

(14 citation statements)

References 80 publications

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“…COPD is characterized by progressive and not fully reversible airflow limitation, accompanied by infiltration of the airways by neutrophils and mucus hypersecretion (2,3). Acute exacerbations of COPD (AECOPD) are episodes of increased respiratory and systemic symptoms, mostly caused by bacterial and viral infections (4).…”

Section: N Ontypeable (Noncapsulated) Haemophilus Influenzae (Nthi)mentioning

confidence: 99%

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Euba

Moleres

Viadas

et al. 2015

Antimicrob Agents Chemother

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Section: N Ontypeable (Noncapsulated) Haemophilus Influenzae (Nthi)mentioning

confidence: 99%

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Euba

Moleres

Viadas

et al. 2015

Antimicrob Agents Chemother

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“…Na osnovu sprovedenog ispitivanja zaključeno je da elektrokardiogram ima značajnu dijagnostičku vrednost kod bolesnika sa opstruktivnim bronhitisom i da bi kod ovih bolesnika trebalo realizovati elektrokardiografski skrining, pored rutinskih kliničkih istraživanja. Ključne reči: Elektrokardiografija; Hronična opstruktivna bolest pluća; Dijagnoza; Prediktivna vrednost testova as having COPD with either emphysema or chronic bronchitis predominance [3].…”

Section: Introductionunclassified

Analysis of electrocardiogram in chronic obstructive pulmonary disease patients

et al. 2013

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“…42 To date, because of the complexity of the pathogenic processes and the chronic course of disease, there is no effective early disease marker for COPD. [43][44][45] Therefore, the combination of PGF with other surrogate markers may be useful in the early diagnosis of COPD. Figure 4 indicates that the decreased phosphorylation levels of autophagy-associated proteins were modulated by PGF.…”

Section: Downloaded By [University Of Saskatchewan Library] At 15:39 mentioning

confidence: 99%

Elastase induces lung epithelial cell autophagy through placental growth factor

et al. 2014

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Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated with increasing mortality and morbidity. Therefore, there is a need to clearly define the COPD pathogenic mechanism and to explore effective therapies. Previous studies indicated that cigarette smoke (CS) induces autophagy and apoptosis in lung epithelial (LE) cells. Excessive ELANE/HNE (elastase, neutrophil elastase), a factor involved in protease-antiprotease imbalance and the pathogenesis of COPD, causes LE cell apoptosis and upregulates the expression of several stimulus-responsive genes. However, whether or not elastase induces autophagy in LE cell remains unknown. The level of PGF (placental growth factor) is higher in COPD patients than non-COPD controls. We hypothesize that elastase induces PGF expression and causes autophagy in LE cells. In this study, we demonstrated that porcine pancreatic elastase (PPE) induced PGF expression and secretion in LE cells in vitro and in vivo. The activation of MAPK8/JNK1 (mitogen-activated protein kinase 8) and MAPK14/p38alpha MAPK signaling pathways was involved in the PGF mediated regulation of the TSC (tuberous sclerosis complex) pathway and autophagy in LE cells. Notably, PGF-induced MAPK8 and MAPK14 signaling pathways mediated the inactivation of MTOR (mechanistic target of rapamycin), the upregulation of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 β) and the increase of autophagosome formation in mice. Furthermore, the PPE-induced autophagy promotes further apoptosis in vitro and in vivo. In summary, elastase-induced autophagy promotes LE cell apoptosis and pulmonary emphysema through the upregulation of PGF. PGF and its downstream MAPK8 and MAPK14 signaling pathways are potential therapeutic targets for the treatment of emphysema and COPD.

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Update in Chronic Obstructive Pulmonary Disease 2011

Cited by 22 publications

References 80 publications

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Analysis of electrocardiogram in chronic obstructive pulmonary disease patients

Elastase induces lung epithelial cell autophagy through placental growth factor

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