2001
DOI: 10.1007/978-1-4757-3401-0_8
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Update: High altitude pulmonary edema

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Cited by 42 publications
(20 citation statements)
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“…The observation that inhaled NO did not completely normalize PAP in HAPE-susceptible individuals, but did so in those resistant to HAPE (5,16), indicates that impaired NO synthesis cannot fully account for the excessive pulmonary vascular reactivity in HAPE-prone subjects. It is likely that additional factors, such as increased sympathetic activity or other vasoconstrictors such as angiotensin II (15), endothelin (93), or arachadonic acid metabolites (98) contribute to the increased PAP in HAPE-susceptible subjects.…”
Section: Mechanisms Accounting For Enhanced Hpvmentioning
confidence: 97%
“…The observation that inhaled NO did not completely normalize PAP in HAPE-susceptible individuals, but did so in those resistant to HAPE (5,16), indicates that impaired NO synthesis cannot fully account for the excessive pulmonary vascular reactivity in HAPE-prone subjects. It is likely that additional factors, such as increased sympathetic activity or other vasoconstrictors such as angiotensin II (15), endothelin (93), or arachadonic acid metabolites (98) contribute to the increased PAP in HAPE-susceptible subjects.…”
Section: Mechanisms Accounting For Enhanced Hpvmentioning
confidence: 97%
“…It has been well demonstrated that hypoxia at high altitude is responsible for an increase in the risk of acute mountain sickness [4,5]. In this regard, Goerre et al [6] reported that the degree of hypoxiainduced acute pulmonary hypertension was associated with increased plasma endothelin-1 (ET-1) levels in healthy mountaineers.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 The increased venular tone with increased capillary pressure that follows rapid ascent to high altitude without adequate acclimatization 3 may contribute to force liquid across the endothelial barrier into the interstitial space, which may contribute to respiratory problems in this condition. Because tens of thousands of tourists travel to a variety of high-altitude destinations around the world on a yearly basis, the search for new strategies to prevent and treat high-altitude-induced pulmonary hypertension is now considered a priority.…”
mentioning
confidence: 99%