Update: evidence of a broad histamine footprint on the human exercise transcriptome

Implementation of a Physical Activity Program Protocol in Schoolchildren: Effects on the Endocrine Adipose Tissue and Cognitive Functions

“…With regard to the brain molecular functions studied, NGF is highly expressed in developing hippocampus and cerebral cortex (88), enhances cholinergic neurons differentiation and survival (24), acetylcholine biosynthesis as well as activity and expression of cholinergic markers, improving overall cognitive function (25). As previously reported, exercise increases NGF production (89), results in agreement with those obtained in the current study. One of the most outstanding results is the increase in the BDNF levels in the exercise group.…”

Effect of histamine‐receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study

“…A smaller rise in magnitude of leukocytes and neutrophils was observed following the 60 min of moderate intensity aerobic exercise but this rise was not affected by histamine blockade. These findings were counter to our hypothesis and our expectations, but this response pattern is compatible with our previous observations of (1) a substantial rise of intramuscular histamine during exercise (Romero, McCord, et al., 2016b), (2) a histamine‐mediated elevation of skeletal muscle blood flow following exercise that last hours (McCord et al., 2006; McCord & Halliwill, 2006), (3) an increase in expression of immune function genes following exercise that is altered with histamine blockade (Romero et al., 2018). These observations may link with the many associations between histamine and inflammatory responses outside of exercise (Nettis et al., 2005; Noli & Miolo, 2001; Numata et al., 2006; Yoshida et al., 1989).…”

“…Histamine is a molecule most associated with inflammatory and immune responses. The discovery that histamine concentrations are increased within skeletal muscle during exercise has led to a number of intriguing observations, including the key finding that histamine had a broad impact on the exercise transcriptome (Romero et al., 2018; Romero, Hocker, et al., 2016a) and is critical to the robust adaptations to exercise training (Van der Stede et al., 2021). The idea, that exercise initiates a pro‐inflammatory state, suggests an important role for histamine in this process.…”

“…Although the physiological significance of the exercise induced elevation in histamine is unknown, our lab has demonstrated that systemically blocking histamine H 1 and H 2 receptors blunts sustained post‐exercise vasodilation and reduces skeletal muscle blood flow in the initial hours following exercise (McCord et al., 2006; McCord & Halliwill, 2006). Additionally, recent work from our laboratory has shown that blocking histamine receptors during aerobic exercise alters the expression of ~800 protein coding‐genes associated with the exercise responsome (Ely, 2020; Romero et al., 2018; Romero, Hocker, et al., 2016a). Among the altered protein coding genes are the genes for interleukin 6 (IL‐6), monocyte chemoattractant protein‐1 (MCP‐1), interleukin 1 receptor‐like 1 (IL1RL1) and others involved with immune signaling pathways (Romero et al., 2018; Romero, Hocker, et al., 2016a).…”

“…is unknown, our lab has demonstrated that systemically blocking histamine H 1 and H 2 receptors blunts sustained post-exercise vasodilation and reduces skeletal muscle blood flow in the initial hours following exercise . Additionally, recent work from our laboratory has shown that blocking histamine receptors during aerobic exercise alters the expression of ~800 protein coding-genes associated with the exercise responsome (Ely, 2020;Romero et al, 2018;Romero, Hocker, et al, 2016a). Among the altered protein coding genes are the genes for interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), interleukin 1 receptor-like 1 (IL1RL1) and others involved with immune signaling pathways (Romero et al, 2018;Romero, Hocker, et al, 2016a).…”