Update Breast Cancer 2023 Part 2 – Advanced-Stage Breast Cancer

Abstract

In recent years, a number of new therapies have led to advances in the treatment of patients with advanced breast carcinoma. These substances are mainly CDK4/6 inhibitors and other substances that can overcome endocrine resistance, oral selective estrogen receptor degraders, antibody drug conjugates (ADCs), and PARP inhibitors. This review summarizes and evaluates the latest study results that have been published in recent months. This includes the overall survival data of the Destiny-Breast03 study, the first analysis of the CAPItello-291 study, the comparison of CDK4/6 inhibitor treatment with chemotherapy in the first line of therapy (RIGHT Choice study), the first analysis of the Destiny-Breast02 study in the treatment setting after T-DM1 treatment, and the first analysis of the Serena-2 study.Most of these studies have the potential to significantly change the therapeutic landscape for patients with advanced breast carcinoma and show that the continued rapid development of new therapies is always producing new results.

Spiritual care needs and their attributes among Chinese inpatients with advanced breast cancer based on the Kano model: a descriptive cross-sectional study

“…Additionally, they may experience an increase in the burden of self-feeling, which may lead to a range of negative emotions, including anxiety, depression, inferiority, fear, and even suicidal thoughts [ 10 ]. As a result, to effectively confront disease, family, and life, they desperately require external support and assistance to validate the worth of self-existence and discover the meaning and purpose of life [ 6 ]. According to the findings of Li et al [ 46 ], the majority of inpatients with advanced breast cancer also want to connect with positive and optimistic people and things while undergoing treatment and learning about their prognosis.…”

“…During treatment, the patient will have significant social, psychological, and spiritual challenges related to altered body image, role changes, transformed sexual life, and fear of cancer recurrence [ 5 ]. Patients are particularly more severe if they have advanced breast cancer [ 6 ]. Therefore, spiritual care is necessary for patients with advanced breast cancer for them to overcome pain; appreciate the value of life; and find spiritual sustenance, gain hope, love, forgiveness, and strength, that is spiritual care needs [ 7 , 8 ].…”

Attrition in the First Three Therapy Lines in Patients with Advanced Breast Cancer in the German Real-World PRAEGNANT Registry

“…However, real-world registries could substantially contribute to understanding patient selection patterns and therapy sequences. With a growing number of novel therapy regimes that can improve overall survival, therapy sequences are becoming increasingly important 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 34 . Indeed, acquired resistance mechanisms could affect future therapy lines.…”