Upconverting Nanoparticles

Wang, Haiqiao; Nann, Thomas

doi:10.1007/4243_2010_8

Cited by 12 publications

(5 citation statements)

References 56 publications

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“…Lanthanide oxide nanoparticles have also been under extensive research [65][66][67][68][69]. Lanthanide-based upconversion nanoparticles have been widely studied due to their unique luminescent properties [70][71][72][73][74][75][76], and the properties of these nanostructures are discussed more closely under chapter [150].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Lanthanide Nanoparticules as Photoluminescent Reporters

Soukka

Härmä

2010

Lanthanide Luminescence

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Luminescent lanthanide nanoparticles provide a combination of high luminescence intensity, long luminescence lifetime, sharp emission peaks with narrow bandwidth, and a large Stokes' shift, leading to a high-performance reporter technology for bioanalytical assays. The high specific activity of luminescent lanthanide nanoparticles enables improved assay sensitivities compared to the conventional fluorescent reporters, and the different luminescent lanthanide ions with well-separated emission wavelengths facilitate multiparametric assays. The versatility of lanthanide chelate-doped polymeric nanoparticles as reporters is further increased by the use of the most effective organic light-harvesting ligands optimized for enhanced luminescence and the availability of inexpensive highpower solid-state light sources. Moreover, entrapping within polymeric nanoparticles allows the use of the lanthanide complexes with a weak water solubility or a low thermodynamic stability. In this review, we discuss the effects of nanoparticle composition, particle size, synthesis, surface modification, and biomolecule conjugation on the assay performance in addition to applications of these reporters in both heterogeneous and homogeneous assays. In the future, additional value may be provided by hybrid lanthanide nanoparticles, which combine, e.g., luminescent and magnetic properties for detection and controlling the assay kinetics and washing efficiency.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Lanthanide Nanoparticules as Photoluminescent Reporters

Soukka

Härmä

2010

Lanthanide Luminescence

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“…Sensitized ions (such as Yb 3+ ) usually maintain only one excited 4f state. The electronic transition energy in the energy states of individual f–f state resonated with 980 nm radiation [ 48 ]. The energy gap in this transition overlaps strongly with many of the f–f electron transitions to the lanthanide activator ions used in the UC system, and then the efficient fluorescence resonance energy transferred will happen [ 49 ].…”

Section: The Fundamentals Of Ucnp Compositionmentioning

confidence: 99%

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

et al. 2020

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Multifunctional lanthanide-based upconversion nanoparticles (UCNPs), which feature efficiently convert low-energy photons into high-energy photons, have attracted considerable attention in the domain of materials science and biomedical applications. Due to their unique photophysical properties, including light-emitting stability, excellent upconversion luminescence efficiency, low autofluorescence, and high detection sensitivity, and high penetration depth in samples, UCNPs have been widely applied in biomedical applications, such as biosensing, imaging and theranostics. In this review, we briefly introduced the major components of UCNPs and the luminescence mechanism. Then, we compared several common design synthesis strategies and presented their advantages and disadvantages. Several examples of the functionalization of UCNPs were given. Next, we detailed their biological applications in bioimaging and disease treatment, particularly drug delivery and photodynamic therapy, including antibacterial photodynamic therapy. Finally, the future practical applications in materials science and biomedical fields, as well as the remaining challenges to UCNPs application, were described. This review provides useful practical information and insights for the research on and application of UCNPs in the field of cancer.

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“…Up-conversion phenomena consist of the luminescence produced when a luminophore is excited with a radiation of lower energy than that corresponding to the emitted light, being classified as an anti-Stokes process. [115] This phenomenon is observed through the continuous excitation of systems doped with transition metals or rare earths and it is considered as a non-linear optic process. The most widely used and known nanoparticles are those based on yttrium fluoride doped with other metal ions.…”

Section: Three-dimensional Compositesmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Rico-Yuste¹,

Carrasco

2019

Polymers

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We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

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Upconverting Nanoparticles

Cited by 12 publications

References 56 publications

Lanthanide Nanoparticules as Photoluminescent Reporters

Lanthanide Nanoparticules as Photoluminescent Reporters

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

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