Upconversion raster scanning microscope for long-wavelength infrared imaging of breast cancer microcalcifications

Tseng, Yu-Pei; Bouzy, Pascaline; Pedersen, Christian; Stone, Nick; Tidemand-Lichtenberg, Peter

doi:10.1364/boe.9.004979

Cited by 16 publications

(20 citation statements)

References 28 publications

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“…New applications [132], [136], [180], [222], [223], cross-disciplinary research, and technological improvements would propel this field of research and will potentially result in many more interesting scientific outcomes in the coming years.…”

Section: Discussionmentioning

confidence: 99%

“…However, those systems were limited to small FoV, low conversion efficiency, and narrowband upconversion. In recent years, hyperspectral imaging with wide FoV has been demonstrated including broadband upconversion [45], [47], [94], [125], [162], [180], [181]. For hyperspectral imaging, either a tunable narrowband (e.g., tunable laser, QCL, OPO) or broadband (e.g., Globar, supercontinuum, ASE) IR source is used as illumination.…”

Section: Multi-dimensional Upconversion Imagingmentioning

confidence: 99%

“…For tunable narrowband IR illumination, at each incoming λIR, the PM condition is tuned either by rotating the crystal [69], [104], [125], by changing the temperature of the crystal [19], [45], [69], by raster-scanning the object [44], [180], or by tuning the pump wavelength [93]. For example, Junaid et al [125] calculated the narrow annular FoV for each rotation angle of their nonlinear crystal (AgGaS2) at a fixed λIR of 6.9 µm (see Fig.…”

Section: Multi-dimensional Upconversion Imagingmentioning

confidence: 99%

“…Recently, Tseng et al [180], [185] exploited raster-scannig based wide FoV upconversion imaging using a bulk nonlinear crystal (AgGaS2). They utilized the sample-scanning technique in a microscope setting to get high-resolution images in the 9 -12 µm IR range, using a tunable QCL for IR illumination (50 ns pulse).…”

Section: 1b Label-free Breast Cancer Tissue Diagnosticsmentioning

confidence: 99%

“…A CW 1064 nm laser of 3 W power is used as single-pass pump for the upconversion process. The estimated spatial resolution is ~ 35 µm[180]…”

mentioning

confidence: 99%

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Parametric upconversion imaging and its applications

Barh¹,

Rodrigo²,

Meng³

et al. 2019

Adv. Opt. Photon.

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This article provides an extensive survey of nonlinear parametric upconversion infrared (IR) imaging, starting from its origin to date. Upconversion imaging is a successful innovative technique for IR imaging in terms of sensitivity, speed, and noise performance. In this approach, the IR image is frequency upconverted to form a visible/near-IR image through parametric three-wave mixing followed by detection using a silicon-based detector or camera. In 1968 (50 years back), J. E. Midwinter first demonstrated upconversion imaging from shortwave-IR (1.6 μm) to visible (484 nm) wavelength using a bulk lithium niobate crystal. This technique quickly gained interest, and several other groups demonstrated upconversion imaging further into the mid-and far-IR with significantly improved quantum efficiency. Although a few excellent reviews on upconversion imaging were published in the early 1970's, the rapid progress in recent years merits an updated comprehensive review. The topic includes linear imaging, nonlinear optics, and laser science, and has shown diverse applications. The scope of this article is to provide an in-depth knowledge of upconversion imaging theory. An overview of different phase matching conditions for the parametric process and the sensitivity of the upconversion detection system are discussed. Furthermore, different design considerations and optimization schemes are outlined for application-specific upconversion imaging. The article comprises a historical perspective of the technique, its most recent technological advances, specific outstanding issues, and some cutting-edge applications of upconversion in IR imaging.

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Section: Discussionmentioning

confidence: 99%

Section: Multi-dimensional Upconversion Imagingmentioning

confidence: 99%

Section: Multi-dimensional Upconversion Imagingmentioning

confidence: 99%

Section: 1b Label-free Breast Cancer Tissue Diagnosticsmentioning

confidence: 99%

“…A CW 1064 nm laser of 3 W power is used as single-pass pump for the upconversion process. The estimated spatial resolution is ~ 35 µm[180]…”

mentioning

confidence: 99%

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Parametric upconversion imaging and its applications

Barh¹,

Rodrigo²,

Meng³

et al. 2019

Adv. Opt. Photon.

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Li_xAg_1–_xGaSe₂: Interplay Between Lithium and Silver in Mid‐Infrared Nonlinear Optical Chalcogenides

Исаенко

Dong

Kurus

et al. 2022

Advanced Optical Materials

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AgGaSe2 and LiGaSe2 are two famous mid‐infrared nonlinear optical (NLO) materials with similar chemical formula but different structural symmetry. The former material has relatively larger NLO effect and birefringence but rather small energy band gap, while the latter is the opposite. Aiming at achieving a good balance of NLO properties, here the substitution between silver and lithium ions on the evolution of structural and optical properties in a new series of LixAg1–xGaSe2 crystals is systematically investigated. It reveals that, with the increase of Li content, LixAg1–xGaSe2 almost keeps the same tetragonal symmetry with AgGaSe2 until x ≈ 0.9. The NLO effects and birefringence values vary with respect to x with the largest variation at x = 0.8–0.9. The optimal combination of birefringence (0.03–0.025) and nonlinear parameters (26–30 pm V−1) is achieved at x = 0.4–0.5. As the energy band gap increases with the increase of x, the maximal value of 2.2 eV for chalcopyrite structure suggests that the laser‐induced damage threshold of LixAg1–xGaSe2 would be as large as five‐fold of AgGaSe2. This study provides a good example to show that the rational substitution between Li and Ag can significantly improve the balance of NLO properties in chalcogenides.

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Infrared spectroscopic imaging: a case study for digital molecular histopathology

Mittal

Yeh

et al. 2020

Molecular and Laser Spectroscopy

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Upconversion raster scanning microscope for long-wavelength infrared imaging of breast cancer microcalcifications

Cited by 16 publications

References 28 publications

Parametric upconversion imaging and its applications

Parametric upconversion imaging and its applications

Li_xAg_1–_xGaSe₂: Interplay Between Lithium and Silver in Mid‐Infrared Nonlinear Optical Chalcogenides

Infrared spectroscopic imaging: a case study for digital molecular histopathology

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Upconversion raster scanning microscope for long-wavelength infrared imaging of breast cancer microcalcifications

Cited by 16 publications

References 28 publications

Parametric upconversion imaging and its applications

Parametric upconversion imaging and its applications

LixAg1–xGaSe2: Interplay Between Lithium and Silver in Mid‐Infrared Nonlinear Optical Chalcogenides

Infrared spectroscopic imaging: a case study for digital molecular histopathology

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Product

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Li_xAg_1–_xGaSe₂: Interplay Between Lithium and Silver in Mid‐Infrared Nonlinear Optical Chalcogenides