Upconversion rare earth nanoparticles functionalized with folic acid for bioimaging of MCF-7 breast cancer cells

Chávez-García, D.; Juárez-Moreno, Karla; Campos, Cristian H.; Alderete, Joel B.; Hirata, G. A.

doi:10.1557/jmr.2017.463

Cited by 21 publications

(11 citation statements)

References 17 publications

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“…Therefore, a non-metal oxide, Y 2 O 3 nanoparticles have numerous applications in chemical synthesis, mechanical polishing and as additives to drugs, cosmetics, varnishes and food. Y 2 O 3 nanoparticles are gaining interest for application in photodynamic therapy and biological imaging of cancerous cells 7–9. Also, Gao et al (2019)10 have reported that bone marrow tissue was damaged by Y 2 O 3 nanoparticles’ exposure.…”

Section: Introductionmentioning

confidence: 99%

<p>Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells</p>

Alzahrani¹,

Katubi²,

Ali³

et al. 2019

IJN

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BackgroundYttria-stabilized zirconia (Y2O3/ZrO2) nanoparticles are one of the important nanoparticles extensively used in manufacturing of plastics, textiles, catalyst, etc. Still, the cytotoxic and apoptotic effects of yttria-stabilized zirconia nanoparticles have not been well identified on human skin keratinocyte (HaCaT) cells. Therefore, in this study, we have designed to examine the cytotoxic potential of yttria-stabilized zirconia nanoparticles in HaCaT cells.MethodsPrior to treatment, the yttria-stabilized zirconia nanoparticles were characterized by using different advanced instruments viz. dynamic light scattering (DLS), scanning electron microscope (SEM) and transmission electron microscope (TEM). Cell viability of HaCaT cells was measured by using MTS and NRU assays and viability of cells was reduced in a dose- and time-dependent manner.ResultsReduction in the viability of cells was correlated with the rise of reactive oxygen species generation, increased caspase-3, mitochondria membrane potential and evidence of DNA strand breakage. These were consistent with the possibility that mitochondria damage can play a significant role in the cytotoxic response. Moreover, the activity of oxidative enzymes such as lipid peroxide (LPO) was increased and glutathione was reduced in HaCaT cells exposed with yttria-stabilized zirconia nanoparticles. It is also important to indicate that HaCaT cells appear to be more susceptible to yttria-stabilized zirconia nanoparticles exposure after 24 hrs.ConclusionThis result provides a dose- and time-dependent apoptosis and genotoxicity of yttria-stabilized zirconia nanoparticles in HaCaT cells.

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Section: Introductionmentioning

confidence: 99%

<p>Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells</p>

Alzahrani¹,

Katubi²,

Ali³

et al. 2019

IJN

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“…In detail, A549 cells were incubated with different formulations (with or without BSA pretreatment) for different time intervals. Afterwards, cells were detached and subjected to FCM analysis of intracellular DOX content [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Effective Chemotherapy of Lung Cancer Using Bovine Serum Albumin-Coated Hydroxyapatite Nanoparticles

Tang

Wang

et al. 2020

Med Sci Monit

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Background Successful chemotherapy of lung cancer relies largely on the use of a good drug delivery system (DDS). We successfully constructed a hybrid DDS comprised of hydroxyapatite (HAP) nanoparticles and bovine serum albumin (BSA). Material/Methods The HAP nanoparticles were selected as the core to encapsulate the anticancer drug doxorubicin (DOX), followed by surface modification of BSA as a stabilizer and shielding corona to finally prepare the hybrid DDS (BSA/HAP/DOX). Results The following characterizations revealed that BSA/HAP nanoparticles have high stability, high biocompatibility, and good DOX-loading capability to meet in vivo applications. Moreover, BSA/HAP/DOX can enhance the cellular uptake of drug in A549 cells (lung cancer cells). Most importantly, BSA/HAP had better in vivo tumor targetability than bare HAP nanoparticles, which resulted in stronger anticancer efficacy both in vitro and in vivo than free DOX or HAP/DOX, and greatly decreased the adverse effects of free DOX. Conclusions Our hybrid DDS shows potential to be applied in more advanced application of cancer therapy.

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“…The functionalization with FA ligands was also reported [38], it was done in a Schlenk system in a N2 atmosphere. FA and TEA were added in 10 ml of dry DMSO and they were agitated for 2h at 37°C.…”

Section: Dcnps Synthesis and Functionalizationmentioning

confidence: 98%

Nanotoxicological Assessments to Warranty the use of Functionalized Y2O3 Nanoparticles for Biomedical Applications

Chávez-García¹,

Juárez-Moreno²,

Reyes³

et al. 2020

Adv. Mater. Lett.

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Upconversion rare earth nanoparticles functionalized with folic acid for bioimaging of MCF-7 breast cancer cells

Abstract: Abstract

Cited by 21 publications

References 17 publications

<p>Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells</p>

<p>Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells</p>

Effective Chemotherapy of Lung Cancer Using Bovine Serum Albumin-Coated Hydroxyapatite Nanoparticles

Nanotoxicological Assessments to Warranty the use of Functionalized Y2O3 Nanoparticles for Biomedical Applications

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