Upconversion Nanoparticles/Hyaluronate–Rose Bengal Conjugate Complex for Noninvasive Photochemical Tissue Bonding

Han, Seulgi; Hwang, Byung Woo; Jeon, Eun Young; Jung, Dooyup; Lee, Geon Hui; Keum, Do Hee; Kim, Ki Su; Yun, Seok Hyun; Joon, Hyung; Hahn, Sei Kwang

doi:10.1021/acsnano.7b04153

Cited by 85 publications

(55 citation statements)

References 36 publications

(58 reference statements)

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“…Owing to the superior tissue penetration ability of NIR laser source (e.g. 808 nm, 980 nm, etc), success in non-invasive photochemical tissue bonding and tumor-induced wound healing has been achieved [6][7][8]. Such reports indicate the enormous potential of using NIR driven upconversion nanoparticle (UCNP) in non-invasive treatment of sub-cutaneous cancer and skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Facile transdermal delivery of upconversion nanoparticle by iontophoresis-responsive magneto-upconversion oleogel

et al. 2020

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The effective application of upconversion nanoparticle (UCNP) as a photo-medicine in skin cancers critically depends on a facile transdermal delivery process through topical route. Herein, combining two non-invasive techniques, i.e. skin permeation enhancement and alternating current (AC) induced iontophoresis, we report a controlled transdermal delivery of UCNP with a time advantage. We have synthesized a series of soybean oil-based oleogels termed as magneto-upconversion (MU) gels by incorporating a fixed amount of UCNP and different proportions of magnetic nanoparticle (MNP) using stearic acid-based gelator as a skin permeation enhancing agent. The microstructures of the synthesized MU gels were characterized by microscopy, X-Ray diffraction and vibrational spectroscopy. A detailed analysis of the electrical properties revealed a gradual increase in the electrical conductance in the MU gel series with increasing proportion of MNP. Such trend of conductance imparted proportional iontophoretic response within the respective MU gels, validated through the release of ciprofloxacin hydrochloride as a model drug preloaded within the oleogels. Through a series of skin permeation experiment using pig ear skin as animal model, we established that the UCNP was able to permeate the whole thickness of the skin within as little as 3 h, only when the two conditions, i.e. the presence of skin permeation enhancer and iontophoresis were met. Within the same time, UCNP permeation was enhanced by the presence of MNP in the MU gels upto 2 folds. Our study developed a rational method for the transdermal delivery of any electrically non-conducting nanoparticle in a faster and tunable way. OPEN ACCESS RECEIVED

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Section: Introductionmentioning

confidence: 99%

Facile transdermal delivery of upconversion nanoparticle by iontophoresis-responsive magneto-upconversion oleogel

et al. 2020

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“…7a, while the background autofluorescence level was negligible, the NIR laser completely penetrated the tissue sample and was effectively converted to green UCL by the NIR-to-vis-excited Cit-UCNPs. The tissue penetration depth of a green laser is reported only approximately 0.3 mm 36 .…”

Section: Resultsmentioning

confidence: 99%

Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

et al. 2020

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A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H 2 -evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system in which the lipid bilayer embeds chlorophyll a (Chla). The UCNP functions as a transducer, converting NIR light into upconversion luminescence for simultaneous imaging and therapy in situ. Functioning as light-harvesting antennas, AuNPs are used to detect the local concentration of ROS for FRET biosensing, while the Chla activates the photosynthesis of H 2 gas to scavenge local excess ROS. The results thus obtained indicate the potential of using the Lip NPs in the analysis of biological tissues, restoring their ROS homeostasis, possibly preventing the initiation and progression of diseases.

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“…[ 26,53 ] Fourth, NIR light also can be used to modulate electron transfer in cells via the photoelectrochemical nanomaterials (such as silicon‐based nanostructured materials), thus being used for optical neuromodulation and stem cell‐based regenerative medicine. [ 54,55 ]…”

Section: Near‐infrared Light and Its Biomedical Applicationsmentioning

confidence: 99%

Advanced Near‐Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living Systems

et al. 2020

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Light‐based technique, including optical imaging and photoregulation, has become one of the most important tools for both fundamental research and clinical practice, such as cell signal sensing, cancer diagnosis, tissue engineering, drug delivery, visual regulation, neuromodulation, and disease treatment. In particular, low energy near‐infrared (NIR, 700–1700 nm) light possesses lower phototoxicity and higher tissue penetration depth in living systems as compared with ultraviolet/visible light, making it a promising tool for in vivo applications. Currently, the NIR light‐based imaging and photoregulation strategies have offered a possibility to real‐time sense and/or modulate specific cellular events in deep tissues with subcellular accuracy. Herein, the recent progress with respect to NIR light for monitoring and modulating the spatiotemporal dynamics of cell functions in living systems are summarized. In particular, the applications of NIR light‐based techniques in cancer theranostics, regenerative medicine, and neuroscience research are systematically introduced and discussed. In addition, the challenges and prospects for NIR light‐based cell sensing and regulating techniques are comprehensively discussed.

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Upconversion Nanoparticles/Hyaluronate–Rose Bengal Conjugate Complex for Noninvasive Photochemical Tissue Bonding

Cited by 85 publications

References 36 publications

Facile transdermal delivery of upconversion nanoparticle by iontophoresis-responsive magneto-upconversion oleogel

Facile transdermal delivery of upconversion nanoparticle by iontophoresis-responsive magneto-upconversion oleogel

Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

Advanced Near‐Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living Systems

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