2018
DOI: 10.1039/c8cc03480j
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Upconversion nanocrystal ‘armoured’ silica fibres with superior photoluminescence for miRNA detection

Abstract: We have fabricated a flexible membrane, consisting of SiO2 nanofibres armoured with upconversion nanoparticles, exhibiting intense photoluminescence. These assemblies were subsequently grafted with molecular beacons to produce a biosensor suitable for the detection of specific microRNA and with applications in early cancer detection and point-of-care diagnosis.

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Cited by 38 publications
(17 citation statements)
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“…The concentration of DOX in Group (ii) maintained at the same level as that for the DOX-ZnS@SiO 2 fibres in Group (iv) and Group (vi). However, it should be noted that this is relatively low in comparison with that reported in DOX chemotherapy 23 . As shown in Fig.…”
Section: Please Do Not Adjust Marginsmentioning
confidence: 56%
See 1 more Smart Citation
“…The concentration of DOX in Group (ii) maintained at the same level as that for the DOX-ZnS@SiO 2 fibres in Group (iv) and Group (vi). However, it should be noted that this is relatively low in comparison with that reported in DOX chemotherapy 23 . As shown in Fig.…”
Section: Please Do Not Adjust Marginsmentioning
confidence: 56%
“…2b). Flexible silica nanofibres with negative charged surface and inactivity during hydrothermal process enabled the assembly of ZnS nanoparticles 23 .…”
Section: Please Do Not Adjust Marginsmentioning
confidence: 99%
“…The molecular beacon was then coupled to a quencher molecule, leading to luminescence recovery. This sensor offered a quite high LOD of 2 nM [ 177 ]. Another approach used DNA-SiNPs conjugates for miRNA detection.…”
Section: Nanomaterials Used In Liquid Biopsy Applicationsmentioning
confidence: 99%
“…In the other studies, the upconversion nanoparticles (UCNPs) were utilized as fluorescence donor in the FRET‐based biosensing system . Normally, lanthanide or actinide doped transitional metal structures played as UCNPs, and FI was demonstrated through the energy transfer from UCNP to specific fluorescence acceptor.…”
Section: Fluorescent Qds For Biosensing Systemsmentioning
confidence: 99%