Upconversion luminescence–based aptasensor for the detection of thyroid-stimulating hormone in serum

Wavelength-Dependent Metal-Enhanced Fluorescence Biosensors via Resonance Energy Transfer Modulation

“…This CA125 sensor showed a linear range of 0.01–100 pM (0.01–100 U/mL) and a detection limit of 9 fM (9 × 10 −3 U/mL). Recently, Liu et al [ 93 ] reported a quantitative analysis of TSH by RET luminescence mechanism between the UCNPs donor and tetramethylrhodamine receptor. The resulting detection dynamic range and the limit of detection were 0.66–33.26 pM (0.1–5.0 mIU/L) and 0.43 pM (0.065 mIU/L).…”

A Comprehensive Review on Upconversion Nanomaterials-Based Fluorescent Sensor for Environment, Biology, Food and Medicine Applications

“…Early sensitivity analyzation of thyroid-stimulating hormone (TSH) allows for early diagnosis of thyroid related disorders. Liu et al [ 128 ] designed the UCNPs-tetramethylrhodamine (TAMRA) graft aptamers for the detection of TSH. When TSH bound to the aptamer to form a stable hairpin structure, the distance between UCNPs and TAMRA was reduced, thus causing the fluorescence quenching of NaYF 4 : Yb, Er, so that the TSH can be detected rapidly in serum.…”

Luminescence of carbon quantum dots and their application in biochemistry

“…CQDs can produce obvious thermal effect under 980 nm laser irradiation, ablation of tumor cells in focal areas and enhance DOX release. Based on the upconversion luminescence (UCL), the combined material transfers energy to conjugated PDT reagent (ZnPc) to produce ROS to kill tumor cells [ 215 , 216 ]. In addition, a nanoparticle system loaded with Cu2+ and CDs-Ce6 (Cu/CC NPs) using the synergistic principle [ 217 ], partly due to FRET, the assembled Cu/CC NPs hide the fluorescence of CQD, which decomposing and releasing CQD when entering tumor cells as a means of monitoring, the other part of PDT function was effectively restored under the stimulation of tumor microenvironment TME ( Fig.…”