Upconversion-based nanosystems for fluorescence sensing of pH and H<sub>2</sub>O<sub>2</sub>

Sun, Chenglin; Gradzielski, Michael

doi:10.1039/d0na01045f

Cited by 18 publications

(5 citation statements)

References 52 publications

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“…Lanthanide-doped upconversion nanoparticles (UCNPs), as fluorescent nanoparticles, have drawn intense attention in recent decades . Their nonlinear optical features, namely, absorbing near-infrared (NIR) photons and emitting visible and ultraviolet (UV) photons, have been widely exploited and triggered their applications in biomedical fields, , such as biological imaging, , biological detection, , and therapeutics . Incorporation of luminescent nanoparticles in cellulose as photonic/bio-hybrid is also an active area of research.…”

Section: Introductionmentioning

confidence: 99%

3D Printable Hybrid Gel Made of Polymer Surface-Modified Cellulose Nanofibrils Prepared by Surface-Initiated Controlled Radical Polymerization (SI-SET-LRP) and Upconversion Luminescent Nanoparticles

Jiang¹,

Mietner²,

Harder

et al. 2023

ACS Appl. Mater. Interfaces

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A cellulose nanofibril-based hybrid gel material was developed by grafting the polymerized stearyl acrylate (PSA) and upconversion nanoparticles (UCNPs) onto cellulose nanofibrils (CNFs) via Cu0-mediated radical polymerization (SET-LRP) to create a highly cross-linked CNF system. A two-step strategy was exploited to surface-exchange the ligand of the UCNPs from a hydrophobic ligand (oleic acid) to a hydrophilic small-molecule ligand (2-acrylamido-2-methyl-1-propanesulfonic acid, AMPS) and therefore be suitable for SET-LRP. The characteristics and properties of the hybrid material (UCNP-PSA-CNF) were monitored by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, X-ray diffraction (XRD), and microscopic analysis. Those characterization techniques prove the efficient modification of the CNF, with the presence of 1.8% UCNPs. The luminescence measurement was carried out using a homebuilt confocal microscope with a 980 nm laser source. The nanostructure of UCNPs and their incorporated CNF species were measured by small-angle X-ray scattering (SAXS). In addition, this CNF-based hybrid gel has decisive rheological properties, such as good viscoelasticity (loss tangent was below 0.35 for the UCNP-PSA-CNF gel, while the PSA-CNF gel reached the highest value of 0.42), shear-thinning behavior, and shape retention, and was successfully applied to three-dimensional (3D) gel printing throughout various 3D print models.

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Section: Introductionmentioning

confidence: 99%

3D Printable Hybrid Gel Made of Polymer Surface-Modified Cellulose Nanofibrils Prepared by Surface-Initiated Controlled Radical Polymerization (SI-SET-LRP) and Upconversion Luminescent Nanoparticles

Jiang¹,

Mietner²,

Harder

et al. 2023

ACS Appl. Mater. Interfaces

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“…However, in the presence of hydrogen peroxide, that acts as an oxidant to covert free thiol groups to a disulfide bond (S─S) form, eliminating free thiols, and enhances the fluorescence. [85,86] Moreover, the silver NCs gets oxidized to form Ag + ions that cause the structural changes of the NCs by removing closely packed Ag atoms from the NCs helping in the recovery and enhancement of the fluorescence. More detailed studies need to be performed including structural and molecular analysis to exactly understand the mechanisms which is currently planned for subsequent future studies.…”

Section: Bimetallic Nanocomposites Were Utilized For Hydrogen Peroxid...mentioning

confidence: 99%

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

Das

Tripathy

Sreedhar

et al. 2023

Advanced Therapeutics

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Recently, multifunctional metal‐based nanocomposites gained immense importance in various biomedical applications. Here, a simple approach is reported to synthesize fluorescent bimetallic nanocomposites (NCs) of silver‐gold (Ag@Au NC) and silver‐platinum (Ag@Pt NC) by reducing silver nitrate (AgNO3) on gold nanoparticles and platinum nanoparticles (AuNPs, PtNPs), respectively, in the presence of lysozyme that acts as capping agent. Various in vitro (in normal cells including Chinese hamster ovarian and human umbilical vein endothelial cells) and in vivo (in mouse and chicken egg chorioallantoic membrane model) studies reveal the biocompatibility of these nanocomposites. However, these NCs show inhibition of cancer cell proliferation when treated to various cancer cells (MCF‐7, MDA‐MB‐231, and B16F10), indicating their anticancer property. Intraperitoneal administration of these NCs resulted in the regression of melanoma tumor in C57BL/6J mouse model. Further, these NCs displayed green fluorescence inside MCF‐7 cells facilitating in vitro live‐cell imaging and sense hydrogen peroxide (H2O2) in cellular level (B16F10 and MCF‐7) using their fluorescence enhancement property in presence of H2O2.The results (in vitro and in vivo) altogether demonstrate the promising multifunctional applications of bimetallic nanocomposites (NCs) that can be utilized as promising transformative drugs in cancer theranostics applications.

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“…Hydrogen peroxide (H2O2) is an important industrial raw material, which is widely used in the fields of chemical, pharmaceutical and environment, etc [1][2][3] . Research shows that higher levels of H2O2 exposure increase the risk of neurological diseases such as Parkinson's [4,5] .…”

Section: Introductionmentioning

confidence: 99%

CuO modified Si nanowires for enzyme-free photoelectrochemical sensing of H2O2

Zhang¹,

Ke²,

Lu³

et al. 2023

Third Optics Frontier Conference (OFS 2023)

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Constructing novel hybrid nanostructure has become an effective strategy to enhance the performance of photoelectrochemical (PEC) biosensors. However, most of the H2O2-sensing photoelectrodes require enzyme modification, which limits the working environment and sensing performance. Herein, the burr-like CuO nanostructures are modified on the entire surfaces of the ordered Si nanowires (SiNWs) by using a combination of magnetron sputtering and hydrothermal growth. The optimized CuO@SiNWs heterojunction with a core-shell structure enables enzyme-free PEC detection of H2O2, achieving a sensitivity of 227.76 AmM -1 cm -2 in the concentration range of 0-588 mM and a detection limit of 7.14 μM (Signal/Noise=3). The excellent sensing performance of the CuO@SiNWs is attributed to the large specific surface area provided by SiNWs and the CuO possess desired H2O2-catalytic activity while providing a great number of active sites. In addition, the CuO@SiNWs demonstrates satisfactory optical absorption. This work demonstrates that enzyme-free and highly sensitive H2O2 detection can be achieved by hybrid nanostructure, providing an alternative route to H2O2 sensing.

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Upconversion-based nanosystems for fluorescence sensing of pH and H₂O₂

Abstract: Hydrogen peroxide (H2O2), a key reactive oxygen species, plays an important role in living organisms, industrial and environmental fields. Here, a non-contact upconversion nanosystem based on the excitation energy attenuation...

Cited by 18 publications

References 52 publications

3D Printable Hybrid Gel Made of Polymer Surface-Modified Cellulose Nanofibrils Prepared by Surface-Initiated Controlled Radical Polymerization (SI-SET-LRP) and Upconversion Luminescent Nanoparticles

3D Printable Hybrid Gel Made of Polymer Surface-Modified Cellulose Nanofibrils Prepared by Surface-Initiated Controlled Radical Polymerization (SI-SET-LRP) and Upconversion Luminescent Nanoparticles

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

CuO modified Si nanowires for enzyme-free photoelectrochemical sensing of H2O2

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Upconversion-based nanosystems for fluorescence sensing of pH and H2O2

Abstract: Hydrogen peroxide (H2O2), a key reactive oxygen species, plays an important role in living organisms, industrial and environmental fields. Here, a non-contact upconversion nanosystem based on the excitation energy attenuation...

Cited by 18 publications

References 52 publications

3D Printable Hybrid Gel Made of Polymer Surface-Modified Cellulose Nanofibrils Prepared by Surface-Initiated Controlled Radical Polymerization (SI-SET-LRP) and Upconversion Luminescent Nanoparticles

3D Printable Hybrid Gel Made of Polymer Surface-Modified Cellulose Nanofibrils Prepared by Surface-Initiated Controlled Radical Polymerization (SI-SET-LRP) and Upconversion Luminescent Nanoparticles

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

CuO modified Si nanowires for enzyme-free photoelectrochemical sensing of H2O2

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Upconversion-based nanosystems for fluorescence sensing of pH and H₂O₂