Upadacitinib for the Treatment of Moderate-to-Severe Crohn’s Disease
Jurij Hanzel,
Christopher Ma,
Vipul Jairath
Abstract:Despite an increasing number of therapies for Crohn's disease (CD), half of patients do not respond to initial treatment or lose response over time, highlighting the need for novel therapies. Inhibition of Janus kinases (JAKs) has emerged as an important therapeutic target for CD. Upadacitinib is an orally administered selective JAK1 inhibitor, which is effective for the induction and maintenance of remission in moderately-to-severely active CD, including in patients with prior failure of biological therapy. N… Show more
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