Up-to-date studies regarding the determination of sertraline by different analytical methods

Abstract

Sertraline (SER), aka Zoloft, is one of modern antidepressant, it belongs to the selective serotonin reuptake inhibitor class, which functions to raise serotonin levels in the nervous system. SER has both mood-boosting and depressive effects but has bad influence on the gastrointestinal system. The monitor of SER and its major metabolites, desmethyl-SER (DSER) provides useful information that may assist treatments, particularly during adverse reactions or lack of response to the applied therapy. The determination of SER and its metabolites in different samples, like blood, urine, deceased people and water requires various selective, sensitive and reliable analytical methods. These methods would determine and quantify of the whole drug level, as in blood, or unbound form level, as in urine or saliva. The purpose of the current review is to provide a summary of the outcomes of the methods that have been used for the extraction of SER from different sample's types as well as some of the analytical methods that were used for its quantitative analysis. The work targeted the studies of the last decade.