Up-regulation of thymosin β4 is a determinant of the transformed phenotype and invasiveness of mouse fibrosarcoma cells

Nummela, Pirjo; Yin, Miao; Kielosto, Mari; Leaner, Virna D.; Birrer, Michael J.; Hölttä, Erkki

doi:10.1016/s1359-6349(08)71473-3

Cited by 1 publication

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“…Inhibitor Type Evidence in melanoma References c-Jun, Fos TAM67 c-Jun dominant negative derivative peptide Knocks down c-Jun in melanoma cell line from metastatic inguinal lymph node lesion Madireddi et al (2000) Blocked NFκB activation, downregulating genes for invasion and metastasis Matthews et al (2007) Reduced thymosin β4 in primary fibroblasts and melanoma cells Nummela et al (2006) Increased colony formation of primary and metastatic human melanoma cell lines in soft agar, induced vertical growth, loss of contact inhibition, morphology changes…”

Section: Targetmentioning

confidence: 99%

Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis

Neuendorf

Simmons

Boyle

2023

Front. Cell Dev. Biol.

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The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the extracellular matrix, is an absolute requirement for the survival of disseminating and circulating tumour cells (CTCs), and for the seeding of metastatic lesions. In melanoma, a range of intracellular signalling cascades have been identified as potential drivers of anoikis resistance, however a full understanding of the process is yet to be attained. Mechanisms of anoikis resistance pose an attractive target for the therapeutic treatment of disseminating and circulating melanoma cells. This review explores the range of small molecule, peptide and antibody inhibitors targeting molecules involved in anoikis resistance in melanoma, and may be repurposed to prevent metastatic melanoma prior to its initiation, potentially improving the prognosis for patients.

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Section: Targetmentioning

confidence: 99%