Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer

Yang, Fulun; Xu, Peiwen; Yao, Surui; Li, Min; Bian, Zehua; Huang, Zhaohui

doi:10.1016/j.prp.2023.154352

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…STRA6, a membrane protein, plays a vital role in retinol metabolism and facilitates the transportation of retinol into cells [53]. Recent research has uncovered the involvement of STRA6 in tumor initiation and progression as well as that STRA6 is highly expressed in various tumor cells, such as thyroid cancer [54,55], colorectal cancer [56], lung cancer [57], gastric cancer [20,58], etc., and is associated with prognosis. He et al found that STRA6 can promote the progression of thyroid cancer through the ILK/AKT/mTOR axis [55].…”

Section: Discussionmentioning

confidence: 99%

ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling

Zhu,

Zhang,

Bian

et al. 2024

Cancers

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The ANLN gene encodes anillin, a protein that binds to actin. Recent research has identified ANLN’s function in the initiation and advancement of different cancers. However, its impact on gallbladder cancer (GBC) remains unexplored. This study aimed to elucidate its possible molecular mechanisms in GBC. ANLN expression was assessed using quantitative real-time polymerase chain reaction (QRT-PCR), Western blotting (WB), and immunohistochemistry (IHC), revealing elevated levels in GBC tissues. ANLN knockdown resulted in the inhibition of cell proliferation and migration, leading to apoptosis and cell cycle arrest. Conversely, ANLN overexpression had the opposite effects on GBC cells. In vivo experiments confirmed that ANLN knockdown inhibited GBC cell growth. RNA-seq and bioinformatics analysis revealed ANLN’s function in activating the PI3K/AKT signaling pathway. We further confirmed that ANLN could upregulate STRA6 expression, which activated PI3K/AKT signaling to enhance the growth and movement of GBC cells. These findings demonstrate ANLN’s involvement in GBC initiation and progression, suggesting its potential as a novel target for GBC.

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Section: Discussionmentioning

confidence: 99%

ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling

Zhu,

Zhang,

Bian

et al. 2024

Cancers

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“…Owing to this high disease burden, CRC is considered a major global public health concern. Moreover, the prognosis for CRC is poor owing to metastasis, late detection, and limited availability of effective treatments [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor 6 inhibits colorectal cancer progression by suppressing NF-κB signaling

Ma,

Yin,

et al. 2024

Heliyon

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Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer

Cited by 2 publications

References 17 publications

ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling

ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling

Toll-like receptor 6 inhibits colorectal cancer progression by suppressing NF-κB signaling

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