2001
DOI: 10.1042/bj3550361
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Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1α,25-dihydroxyvitamin D3

Abstract: HL60 promyeloid cells express both classes of oestrogen receptor (ERα and ERβ). We show that hydrolysis of oestrone sulphate by steroid sulphatase is a major source of oestrone in HL60 cells, and that most of the released oestrone is not metabolized further to 17β-oestradiol. Treatment of HL60 cells with retinoids or 1α,25-dihydroxyvitamin D3 increased steroid sulphatase mRNA and activity in parallel with the induction of CD11b, an early marker of myeloid differentiation that is expressed before the differenti… Show more

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Cited by 20 publications
(1 citation statement)
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“…The vitamin D receptor also induces transcription of the steroid sulfotransferases SULT2A1 (Echchgadda et al 2004) and SULT2B1b (Seo et al 2013) as well as the phase I monooxygenase CYP3A4 (Ahn et al 2016), among other genes. Interestingly, the induction of STS by vitamin D3 and retinoids was reported in HL60 promyeloid cells (Hughes et al 2001). As net effect, vitamin D transcriptional regulation results in androgen inactivation (Ahn et al 2016) and elevated sulfation activity that might increase the levels of vitamin D sulfate metabolites.…”
Section: Vitamin Dmentioning
confidence: 97%
“…The vitamin D receptor also induces transcription of the steroid sulfotransferases SULT2A1 (Echchgadda et al 2004) and SULT2B1b (Seo et al 2013) as well as the phase I monooxygenase CYP3A4 (Ahn et al 2016), among other genes. Interestingly, the induction of STS by vitamin D3 and retinoids was reported in HL60 promyeloid cells (Hughes et al 2001). As net effect, vitamin D transcriptional regulation results in androgen inactivation (Ahn et al 2016) and elevated sulfation activity that might increase the levels of vitamin D sulfate metabolites.…”
Section: Vitamin Dmentioning
confidence: 97%