Up‐regulation of miR‐130a is related to leg ulcers in sickle cell anaemia

Batista, Thais Helena Chaves; Santana, Rodrigo Marcionilo; Sobreira, Marcondes J; Arcanjo, Gabriela da Silva; Domingos, Igor F.; Pereira-Martins, Diego A; Falcão, Daniela; Oliveira, Jéssica Maria; Batista, Jéssica V G F; Weinhäuser, Isabel; Hatzlhofer, Betânia Lucena Domingues; Júnior, Walter Lins Barbosa; Araújo, Aderson S; Anjos, Ana Claudia; Costa, Fernando Ferreira; Saad, Mario J A; Carvalho, Bruno M.; Vasconcelos, Luydson Richardson Silva; Lucena-Araujo, Antonio R.; Bezerra, Marcos André Cavalcanti

doi:10.1111/bjh.18018

Cited by 2 publications

(2 citation statements)

References 14 publications

(38 reference statements)

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“…102 MiR-130a overexpression was four times higher in SCD patients with ulcers compared to those without ulcers, suggesting miR-130a may play an important role in this complication. 103 de Carvalho-Siqueira et al used whole exome sequencing to identify new candidate genes and found only one variant in the FLG2 gene associated with leg ulcers in SCD patients. 104 This gene has been observed in persistent atopic dermatitis in African Americans and could be involved in leg ulcer development by promoting alterations in the skin barrier.…”

Section: Factors Influencing Healingmentioning

confidence: 99%

“…Overexpression of miR‐130a has been associated with chronic venous ulcers and dysregulated re‐epithelization processes, granulation tissue formation and wound healing 102 . MiR‐130a overexpression was four times higher in SCD patients with ulcers compared to those without ulcers, suggesting miR‐130a may play an important role in this complication 103 …”

Section: Scd Ulcers Start Mostly Like An Ischaemic Ulcermentioning

confidence: 99%

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Controversies in the pathophysiology of leg ulcers in sickle cell disease

Catella,

Guillot,

Nader

et al. 2024

Br J Haematol

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SummaryPatients with sickle cell disease (SCD) often experience painful vaso‐occlusive crises and chronic haemolytic anaemia, as well as various acute and chronic complications, such as leg ulcers. Leg ulcers are characterized by their unpredictability, debilitating pain and prolonged healing process. The pathophysiology of SCD leg ulcers is not well defined. Known risk factors include male gender, poor social conditions, malnutrition and a lack of compression therapy when oedema occurs. Leg ulcers typically start with spontaneous pain, followed by induration, hyperpigmentation, blister formation and destruction of the epidermis. SCD is characterized by chronic haemolysis, increased oxidative stress and decreased nitric oxide bioavailability, which promote ischaemia and inflammation and consequently impair vascular function in the skin. This cutaneous vasculopathy, coupled with venostasis around the ankle, creates an ideal environment for local vaso‐occlusive crises, which can result in the development of leg ulcers that resemble arterial ulcers. Following the development of the ulcer, healing is hindered as a result of factors commonly observed in venous ulceration, including venous insufficiency, oedema and impaired angiogenesis. All of these factors are modulated by genetic factors. However, our current understanding of these genetic factors remains limited and does not yet enable us to accurately predict ulceration susceptibility.

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Section: Factors Influencing Healingmentioning

confidence: 99%

Section: Scd Ulcers Start Mostly Like An Ischaemic Ulcermentioning

confidence: 99%

Controversies in the pathophysiology of leg ulcers in sickle cell disease

Catella,

Guillot,

Nader

et al. 2024

Br J Haematol

View full text Add to dashboard Cite

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miRNA and leptin signaling in metabolic diseases and at extreme environments

Mondal,

Rathor,

Singh

et al. 2024

Pharmacology Res & Perspec

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The burden of growing concern about the dysregulation of metabolic processes arises due to complex interplay between environment and nutrition that has great impact on genetics and epigenetics of an individual. Thereby, any abnormality at the level of food intake regulating hormones may contribute to the development of metabolic diseases in any age group due to malnutrition, overweight, changing lifestyle, and exposure to extreme environments such as heat stress (HS), cold stress, or high altitude (HA). Hormones such as leptin, adiponectin, ghrelin, and cholecystokinin regulate appetite and satiety to maintain energy homeostasis. Leptin, an adipokine and a pleiotropic hormone, play major role in regulating the food intake, energy gain and energy expenditure. Using in silico approach, we have identified the major genes (LEP, LEPR, JAK2, STAT3, NPY, POMC, IRS1, SOCS3) that play crucial role in leptin signaling pathway. Further, eight miRNAs (hsa‐miR‐204‐5p, hsa‐miR‐211‐5p, hsa‐miR‐30, hsa‐miR‐3163, hsa‐miR‐33a‐3p, hsa‐miR‐548, hsa‐miR‐561‐3p, hsa‐miR‐7856‐5p) from TargetScan 8.0 database were screened out that commonly target these genes. The role of these miRNAs should be explored as they might play vital role in regulating the appetite, energy metabolism, metabolic diseases (obesity, type 2 diabetes, cardiovascular diseases, inflammation), and to combat extreme environments. The miRNAs regulating leptin signaling and appetite may be useful for developing novel therapeutics for metabolic diseases.

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Up‐regulation of miR‐130a is related to leg ulcers in sickle cell anaemia

Cited by 2 publications

References 14 publications

Controversies in the pathophysiology of leg ulcers in sickle cell disease

Controversies in the pathophysiology of leg ulcers in sickle cell disease

miRNA and leptin signaling in metabolic diseases and at extreme environments

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