Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy

Liu, Bei; Wang, Tao; Wang, Liang; Wang, Chao; Zhang, Hua; Gao, Guodong

doi:10.1016/j.jns.2011.05.047

Cited by 16 publications

(10 citation statements)

References 22 publications

(26 reference statements)

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“…These neurons have been shown previously to be newly formed neurons around the injury site 10 days after SCI in adult zebrafish (Hui et al ., ). Expression of MVP in different types of neurons is in agreement with reports showing MVP expression in the nervous system of humans, non‐human primates, rodents and electric fish (Herrmann et al ., ; Aronica et al ., ; van Vliet et al ., ; Paspalas et al ., ; Liu et al ., ). In addition to being expressed by newly formed neurons in the vicinity of the central canal, MVP is also expressed by nestin‐immunoreactive neural stem cells that comprise the radial glia‐type progenitor cells lining the central canal as ependymal cells.…”

Section: Discussionmentioning

confidence: 97%

“…MVP is identical to the human lung resistance protein, and its expression is increased in tumours and multiple drug resistance models (Scheffer et al ., , ; Mossink et al ., ; Lloret et al ., ). Interestingly, MVP is also widely expressed in the nervous system of different species (Herrmann et al ., ; Aronica et al ., ; Komori et al ., ; Paspalas et al ., ; Liu et al ., ). The wide expression of MVP in various cell types and considerable phylogenetic conservation point to its important cellular functions (Kedersha et al ., ).…”

Section: Introductionmentioning

confidence: 97%

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Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish

Pan

Lin

et al. 2012

Eur J of Neuroscience

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In contrast to mammals, adult zebrafish recover locomotor functions after spinal cord injury (SCI), in part due to axonal regrowth and regeneration permissivity of the central nervous system. Upregulation of major vault protein (MVP) expression after spinal cord injury in the brainstem of the adult zebrafish prompted us to probe for its contribution to recovery after SCI. MVP is a multifunctional protein expressed not only in many types of tumours but also in the nervous system, where its importance for regeneration is, however, unclear. Using an established zebrafish SCI model, we found that MVP mRNA and protein expression levels were increased in ependymal cells in the spinal cord caudal to the lesion site at 6 and 11 days after SCI. Double immunolabelling showed that MVP was co-localised with Islet-1 or tyrosine hydroxylase around the central canal of the spinal cord in sham-injured control fish and injured fish 11 days after surgery. MVP co-localised with the neural stem cell marker nestin in ependymal cells after injury. By using an in vivo morpholino-based knock-down approach, we found that the distance moved by MVP morpholino-treated fish was reduced at 4, 5 and 6 weeks after SCI when compared to fish treated with standard control morpholino. Knock-down of MVP resulted in reduced regrowth of axons from brainstem neurons into the spinal cord caudal to the lesion site. These results indicate that MVP supports locomotor recovery and axonal regrowth after SCI in adult zebrafish.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish

Pan

Lin

et al. 2012

Eur J of Neuroscience

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“…Likewise, MVP upregulation was noted in the capillary endothelium of the HS tissue in chronic temporal lobe epilepsy (TLE) patients [6]. In a recent article on refractory frontal lobe epilepsy, dramatically increased MVP level was observed in the epileptogenic tissues resected from the patients' frontal cortex, and pathological examination revealed FCD, gliosis and neuronal degeneration [7].…”

Section: Introductionmentioning

confidence: 99%

Absence of association between major vault protein (MVP) gene polymorphisms and drug resistance in Chinese Han patients with partial epilepsy

Luo

Zhang

Long

et al. 2015

Journal of the Neurological Sciences

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“…Extant vaults are associated with signaling pathways (Berger et al 2009) they are known to be upregulated in treatment resistant cancers (Herlevsen et al 2007) and epilepsy (Liu et al 2011), but these clearly were not their original role in protists. Vaults are enriched in tissue types that are involved with scavenging such as in macrophages (Chugani et al 1991) and in lipid rafts (Kowalski et al 2007).…”

Section: Introductionmentioning

confidence: 99%

In Silico Resurrection of the Major Vault Protein Suggests It Is Ancestral in Modern Eukaryotes

Daly

Sutherland-Smith

Penny

2013

Genome Biology and Evolution

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Vaults are very large oligomeric ribonucleoproteins conserved among a variety of species. The rat vault 3D structure shows an ovoid oligomeric particle, consisting of 78 major vault protein monomers, each of approximately 861 amino acids. Vaults are probably the largest ribonucleoprotein structures in eukaryote cells, being approximately 70 nm in length with a diameter of 40 nm—the size of three ribosomes and with a lumen capacity of 50 million Å3. We use both protein sequences and inferred ancestral sequences for in silico virtual resurrection of tertiary and quaternary structures to search for vaults in a wide variety of eukaryotes. We find that the vault’s phylogenetic distribution is widespread in eukaryotes, but is apparently absent in some notable model organisms. Our conclusion from the distribution of vaults is that they were present in the last eukaryote common ancestor but they have apparently been lost from a number of groups including fungi, insects, and probably plants. Our approach of inferring ancestral 3D and quaternary structures is expected to be useful generally.

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Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy

Cited by 16 publications

References 22 publications

Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish

Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish

Absence of association between major vault protein (MVP) gene polymorphisms and drug resistance in Chinese Han patients with partial epilepsy

In Silico Resurrection of the Major Vault Protein Suggests It Is Ancestral in Modern Eukaryotes

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