Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling

He, Shanyang; Zhao, Yunhe; Wang, Xiaoping; Deng, Ying; Wan, Zhiyong; Yao, Shuzhong; Shen, Hongwei

doi:10.1042/bsr20170681

Cited by 34 publications

(36 citation statements)

References 21 publications

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“…Besides, high‐expression of SNHG20 was observed in human gastric cancer cell lines . Similar results about the high‐expression status of SNHG20 expression were found in female common cancers including cervical cancer , ovarian cancer and breast cancer . The expression of SNHG20 in osteosarcoma was still unknown.…”

Section: Discussionmentioning

confidence: 59%

“…Besides, Li et al revealed silencing of SNHG20 inhibited cell proliferation, invasion, and migration, and cell cycle progression in colorectal cancer . The oncogenic function of SNHG20 was also observed in gastric cancer , cervical cancer , ovarian cancer , and breast cancer .…”

Section: Discussionmentioning

confidence: 99%

“…The epithelial–mesenchymal transition (EMT) is a complex and multi‐step biological process that serves as a key role in modulating tumor cell metastasis . SNHG20 has been showed to be involved in EMT process . In order to explore the molecular mechanism of SNHG20 in regulating osteosarcoma cell migration and invasion, we conducted qRT‐PCR to screen the mRNA expression of EMT‐associated molecules including Snail, Slug, ZEB1, ZEB2, E‐Cadherin, and Vimentin.…”

Section: Discussionmentioning

confidence: 99%

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LncRNA SNHG20 is associated with clinical progression and enhances cell migration and invasion in osteosarcoma

Zhang

Ju²,

Zhang³

et al. 2018

IUBMB Life

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SNHG20 is a novel lncRNA which has been showed to be overexpressed and functions as oncogenic lncRNA in several types of human cancer. The role of SNHG20 in osteosarcoma is still unknown. The purpose of our study was to identify the clinical value and biological function of SNHG20 in osteosarcoma. Our results indicated SNHG20 was overexpressed in osteosarcoma tissues and cell lines compared with paired non-tumor tissues and normal human osteoblast cell line, respectively. Moreover, we observed high-expression of SNHG20 was obviously associated with Enneking stage, distant metastasis, and histological grade. SNHG20 expression was negatively associated with overall survival, and high-expression of SNHG20 was an independent unfavorable prognostic factor in osteosarcoma patients. Furthermore, SNHG20 promoted osteosarcoma cell migration and invasion through modulating epithelial-mesenchymal transition -associated genes. In conclusion, SNHG20 is an independent unfavorable prognostic factor in osteosarcoma patients, and functions as an oncogenic lncRNA to modulate tumor cell migration and invasion. © 2018 IUBMB Life, 70(11):1115-1121, 2018.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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LncRNA SNHG20 is associated with clinical progression and enhances cell migration and invasion in osteosarcoma

Zhang

Ju²,

Zhang³

et al. 2018

IUBMB Life

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“…The small nucleolar RNA host gene 20 (SNHG20) lncRNA is located on 17q25.2 and contains 2,183 nucleotides. Several studies have reported that SNHG20 is involved in promoting several common types of human cancer, including hepatocellular carcinoma (Hcc) (14,15), non-small cell lung cancer (NScLc) (16), colorectal cancer (17), ovarian cancer (18), gastric cancer (19) and breast cancer (20). For example, SNHG20 was found to be significantly upregulated in HCC and colorectal cancer, and the high expression of SNHG20 was a predictor of poor prognosis (15,17).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β-catenin signalling pathway

Zhao

Gao

et al. 2018

Int J Mol Med

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The long non‑coding RNA, small nucleolar RNA host gene 20 (SNHG20), is involved in promoting several common types of human cancer, however, the exact function of SNHG20 in the pathogenesis of bladder cancer remains to be elucidated. The present study aimed to examine the regulatory mechanism of SNHG20 underlying the malignant progression of bladder cancer. Reverse transcription‑quantitative polymerase chain reaction and western blotting were used to examine mRNA and protein expression. Cell survival, proliferation, apoptosis, colony formation, migration and invasion were also studied. The resulting data indicated that SNHG20 was significantly upregulated in bladder cancer tissues and cell lines, compared with its expression in adjacent non‑tumour tissues and the SV‑HUC‑1 normal urinary tract epithelial cell line, respectively. In addition, the high expression of SNHG20 was associated with advanced clinical stage, lymph node metastasis, and reduced patient survival rate. The knockdown of SNHG20 caused a significant reduction in cancer cell survival, proliferation, colony formation, migration and invasion, and induced cell apoptosis. Additionally, the inhibition of SNHG20 reduced tumour growth in vivo. Investigations into the mechanism revealed that the inhibition of SNHG20 suppressed the activation of Wnt/β‑catenin signalling and the expression of certain key genes in bladder cancer cells. Taken together, these results indicated that SNHG20 is involved in promoting bladder cancer and may be used as a potential therapeutic target for the treatment of this disease.

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“…Wnt/β-catenin signal pathway has been revealed to be involved in the regulation of cell proliferation, migration, and invasion in certain cancers [29,30]. It was reported that lncRNA SNHG20 could promote the proliferation, migration, and invasion of bladder cancer and ovarian cancer by activating the Wnt/β-catenin signal pathway [27,31]. Moreover, several important pathway was confirmed to be modulated by SNHG20 in various cancers, including GSK-3β/β-catenin signaling pathway in gastric cancer [28], MDM2-p53 pathway and PTEN/PI3K/AKT signaling pathway in glioma [32,33], PI3K/Akt/mTOR signaling pathway in glioblastoma [17], ATM-JAK-PD-L1 pathway in ESCC [25], and MEK/ERK pathway in cervical cancer [34].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of lncRNA SNHG20 as a biomarker in human cancers: a systematic review and meta-analysis

Li¹,

Rui²,

Chen³

et al. 2020

Preprint

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Background: Long noncoding RNA small nucleolar RNA host gene 20 (SNHG20) is a novel oncogene and dysregulated in a variety of human cancers. It has been revealed to be associated with the clinicopathological features and prognosis. However, the prognostic value of SNHG20 in various cancers remains unclear. Therefore, we performed this meta-analysis to evaluate the relationship between SNHG20 expression and clinical outcomes in human cancers.Methods: Comprehensive literature search was performed in PubMed, Web of Science, CNKI and Wangfang databases, and eligible studies were obtained according to the inclusion and exclusion criteria. The pooled hazard ratios (HRs) and odds ratios (ORs) were applied to assess the clinical value of SNHG20 expression for overall survival (OS) and clinicopathological features.Results: A total of 16 articles including 1190 cancer patients were included in the study. The pooled results demonstrated that evaluated SNHG20 expression was positively related to a poorer OS of cancers (HR=2.36, 95%CI: 1.85-2.87, P<0.001). Subgroup analysis revealed that SNHG20 overexpression was closely related to the low OS of patients with the digestive system cancer (HR=2.92, 95%CI: 1.96-3.88, P<0.001), sample size >80 (HR=2.42, 95%CI: 1.69-3.14, P<0.001), direct HR estimation method (HR=2.65, 95%CI: 1.78-3.52, P<0.001), and median ratio as cut-off value (HR=2.21, 95%CI: 1.60-2.83, P<0.001). In addition, the pooled data also showed that SNHG20 was positively linked to lymph node metastasis (LNM) (OR=1.65, 95%CI: 1.21-2.26, P=0.002), distant metastasis (DM) (OR=1.76, 95%CI: 1.10-2.83, P=0.02), and advanced TNM stage (OR=1.79, 95%CI: 1.34-2.39, P<0.001). Moreover, the results of the trim and fill analysis confirmed the reliability of our finding. Conclusions: Upregulation of SNHG20 was associated with advanced TNM stage, worse LNM and DM, and shorter OS, suggesting that SNHG20 may serve as a biomarker for prognosis and clinicopathological characteristics in human cancers.

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Up-regulation of long non-coding RNA SNHG20 promotes ovarian cancer progression via Wnt/β-catenin signaling

Cited by 34 publications

References 21 publications

LncRNA SNHG20 is associated with clinical progression and enhances cell migration and invasion in osteosarcoma

LncRNA SNHG20 is associated with clinical progression and enhances cell migration and invasion in osteosarcoma

Long non-coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β-catenin signalling pathway

Prognostic value of lncRNA SNHG20 as a biomarker in human cancers: a systematic review and meta-analysis

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