Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression

Yang, Zuozhang; Zhang, Xiao­hong; Gang, Haiju; Li, Xiaojun; Li, Zumao; Wang, Tao; Han, Juan; Luo, Ting; Wen, Fuqiang; Wu, Xiaoting

doi:10.1016/j.bbrc.2007.05.023

Cited by 128 publications

(104 citation statements)

References 26 publications

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“…Data regarding RMS tumors, in general, show high expression of Twist [29]. Twist inhibits factors responsible for miogenesis, such as MyoD [30] and increases N-Cadherin expression [31]. In our study the expression of Twist and Slug was lower in ARMS than in ERMS primary tumors.…”

Section: Discussionsupporting

confidence: 39%

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

PĂźskĂźllĂźoglu

Łukasiewicz²,

Miękus³

et al. 2011

Folia Histochem Cytobiol.

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Section: Discussionsupporting

confidence: 39%

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

PĂźskĂźllĂźoglu

Łukasiewicz²,

Miękus³

et al. 2011

Folia Histochem Cytobiol.

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“…2 c). On the transcriptional level, the transcriptional repressor Twist appears to be involved in the induction of N-cadherin gene expression in an β 1 -integrin-dependent manner [78][79][80]. Like its epithelial counterpart, N-cadherin is connected via α-catenin and β-catenin to the cytoskeleton and functions as both a mechanical cell adhesion component and a signaling molecule.…”

Section: The Cadherin Switch and Its Consequencesmentioning

confidence: 99%

EMT, the cytoskeleton, and cancer cell invasion

Yilmaz

Christofori

2009

Cancer Metastasis Rev

1,533

1,314

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The metastatic process, i.e. the dissemination of cancer cells throughout the body to seed secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to acquire migratory and invasive capabilities. In a process of epithelial-mesenchymal transition (EMT), besides changing their adhesive repertoire, cancer cells employ developmental processes to gain migratory and invasive properties that involve a dramatic reorganization of the actin cytoskeleton and the concomitant formation of membrane protrusions required for invasive growth. The molecular processes underlying such cellular changes are still only poorly understood, and the various migratory organelles, including lamellipodia, filopodia, invadopodia and podosomes, still require a better functional and molecular characterization. Notably, direct experimental evidence linking the formation of migratory membrane protrusions and the process of EMT and tumor metastasis is still lacking. In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side.

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“…Twist expression is mechanosensitive in Drosophila in an Armadillo/ ␤-catenin dependent manner (Farge, 2003), and it is a potent regulator of invasivity in mammalian breast and gastric cancers (Howe et al, 2003;Ma et al, 2007;Yang et al, 2007). As with Myc, a mechanical deformation of 20 min in APC deficient colon tissues induced the expression of Twist1 in both the cytoplasm and some nuclei of crypt cells.…”

Section: Expression Of Myc and Twist1 Are Mechanically Induced In Apcmentioning

confidence: 99%

Mechanical factors activateß‐catenin‐dependent oncogene expression in APC^1638N/+mouse colon

et al. 2008

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Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression

Cited by 128 publications

References 26 publications

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

EMT, the cytoskeleton, and cancer cell invasion

Mechanical factors activateß‐catenin‐dependent oncogene expression in APC^1638N/+mouse colon

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Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression

Cited by 128 publications

References 26 publications

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

EMT, the cytoskeleton, and cancer cell invasion

Mechanical factors activateß‐catenin‐dependent oncogene expression in APC1638N/+mouse colon

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Mechanical factors activateß‐catenin‐dependent oncogene expression in APC^1638N/+mouse colon