Biochemical Pharmacology volume 80, issue 4, P463-470 2010 DOI: 10.1016/j.bcp.2010.05.016 View full text
Y. Takano, H. Iwata, Y. Yano, M. Miyazawa, N. Virgona, H. Sato, K. Ueno, T. Yano

Abstract: Enforced expression of connexin (Cx) 32 gene, a member of gap junction gene family and a tumor suppressor gene in human renal cell carcinoma (RCC), enhanced vinblastine (VBL)-induced cytotoxicity on RCC cells, due to the suppression of multidrug resistance 1 (MDR1) gene product, P-glycoprotein (P-gp). Also, Cx32 gene in RCC is silenced by hypermethylation of CpG islands in a promoter region of the Cx gene. In this study, we investigated if a DNA demethylating agent, 5-aza-2'-deoxycytidine (5-Aza) could enhance…

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