Up-regulation of B-cell lymphoma factor-2 expression, inhibition of oxidative stress and down-regulation of pro-inflammatory cytokines are involved in the protective effect of cabbage (Brassica oleracea) juice in lead-induced endothelial dysfunction in rats

Treatment with Ginkgo biloba supplement modulates oxidative disturbances, inflammation and vascular functions in oxygen deprived hypothyroid mice: Involvement of endothelin‐1/NO signaling pathways

“…However, in sickness, it promotes the normal functioning of many tissues and organs of the body (Hernández‐Jiménez et al, 2022; Sanusi et al, 2020). Increased oxidative/nitrosative stress, up‐regulation of inflammatory activity, and, most importantly, defective endothelin/endothelial nitric oxide synthase (eNOS) signaling have all been documented as precursors of endothelial dysfunction (Asiwe, Kolawole, et al, 2022; Jasińska‐Stroschein, 2022; Virk et al, 2021). All of this could be the result of a thyroid hormone‐induced metabolic malfunction and/or cellular stress caused by a lack of vital nutrients (oxygen) (Capelli et al, 2021; Napolitano et al, 2020).…”

“…Many studies have found a link between nutritional deficiency and increased incidences/severity of endothelial dysfunctions (Illiano et al, 2020). Ginkgo biloba supplement (GBS) is a popular commercial medical herb made from the green leaves of the ginkgo tree, one of the world's oldest surviving plant species Adebayo, Asiwe, et al, 2022;Asiwe, Daubry, et al, 2022;Asiwe, Kolawole, et al, 2022).…”

“…antioxidant, aorta, corticosterone, Ginkgo biloba, HPA, thyroid hormone et al, 2022;Asiwe, Daubry, et al, 2022;Asiwe, Kolawole, et al, 2022;Liu et al, 2021). GBS has been found in vivo to enhance blood flow and prevent platelet activating factors.…”

“…GBS is frequently used in the therapeutic treatment of cardiovascular and neurological illnesses, such as Alzheimer's disease (Singh et al, 2019) and Parkinson's disease Adebayo, Asiwe, et al, 2022;Singh et al, 2019). Additionally, anti-inflammatory and antioxidant effects have been demonstrated in GBS by Adebayo et al (2021) and Asiwe, Kolawole, et al (2022); Asiwe, Daubry, et al (2022). The impact of GBS on endothelial function in hypothyroid animals exposed to hypoxia is not fully understood.…”

“…Many studies have found a link between nutritional deficiency and increased incidences/severity of endothelial dysfunctions (Illiano et al, 2020). Ginkgo biloba supplement (GBS) is a popular commercial medical herb made from the green leaves of the ginkgo tree, one of the world's oldest surviving plant species (Adebayo, Aduema, et al, 2022; Adebayo, Asiwe, et al, 2022; Asiwe, Daubry, et al, 2022; Asiwe, Kolawole, et al, 2022). It is known to contain secondary metabolites with abundance of flavonoid glycosides (Adebayo, Aduema, et al, 2022; Adebayo, Asiwe, et al, 2022; Asiwe, Daubry, et al, 2022; Asiwe, Kolawole, et al, 2022; Liu et al, 2021).…”