2019
DOI: 10.1016/j.ijpara.2018.05.015
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Up-regulated expression of spherical body protein 2 truncated copy 11 in Babesia bovis is associated with reduced cytoadhesion to vascular endothelial cells

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Cited by 17 publications
(25 citation statements)
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“…The anti-BcSBP4 peptide antibodies react with an antigen that appears to be localized in internal parasite organelles and also in the erythrocyte cytoplasm. This pattern of reactivity is compatible with spherical body localization and comparable to what was observed for other spherical body proteins in the related parasites B. bovis, B. bigemina and B. orientalis [13,23,24].…”
Section: Resultssupporting
confidence: 88%
“…The anti-BcSBP4 peptide antibodies react with an antigen that appears to be localized in internal parasite organelles and also in the erythrocyte cytoplasm. This pattern of reactivity is compatible with spherical body localization and comparable to what was observed for other spherical body proteins in the related parasites B. bovis, B. bigemina and B. orientalis [13,23,24].…”
Section: Resultssupporting
confidence: 88%
“…Because we could not co-precipitate these two proteins by immunoprecipitation experiments (S8B Fig), they may not directly interact. Recently it was shown that upregulation of SBP2 truncated copy 11 in B. bovis reduced binding of iRBCs to endothelial cells and its virulence in cattle [43,44]. However, it is unclear how SBP2 truncated copy 11 affects the export or surface expression of VESA1 or other putative cytoadhesion ligands.…”
Section: Plos Pathogensmentioning
confidence: 99%
“…A GFP expressing parasite is advantageous for the drug screening and in vivo tracking of the parasite location during infection. Studies have shown that transfection in B. bovis, to study the gene function, were helpful in developing vaccine against bovine babesiosis 29 , 30 . Therefore, a transgenic B. microti parasite will also be helpful in study of gene function and vaccine development.…”
Section: Discussionmentioning
confidence: 99%
“…Studies have shown that transfection in B. bovis, to study the gene function, were helpful in developing vaccine against bovine babesiosis 29,30 . Therefore, a transgenic B. microti parasite will also be helpful in study of gene function and vaccine development.…”
Section: Primers Sequencementioning
confidence: 99%