Up-regulated CCL18, CCL28 and CXCL13 Expression is Associated with the Risk of Gastritis and Peptic Ulcer Disease in Helicobacter Pylori infection

Sanaei, Mohammad‐Javad; Shirzad, Hedayatollah; Soltani, Amin; Abdollahpour‐Alitappeh, Meghdad; Shafigh, Mohammadhadi; Rahimian, Ghorbanali; Mirzaei, Yousef

doi:10.1016/j.amjms.2020.07.030

Cited by 12 publications

(10 citation statements)

References 37 publications

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“…Helicobacter pylori is recognized as the cause of gastritis, gastrointestinal ulcers and gastric carcinoma (gastric, intestinal ulcers), MALT lymphoma, and non-gastric diseases associated with Helicobacter pylori (Azadegan-Dehkordi et al 2020 ; Fujikawa et al 2003 ; Khaledi et al 2020 ; Lee et al 2005 ; Sanaii et al 2019 ). The outcome of infection with this bacterium depends on several factors such as bacterial isolates, host inflammatory responses, host genetic diversity, and environmental factors (Montecucco de Bernard 2003 ; Nahid-Samiei et al 2020 ; Rhead et al 2007 ; Sanaei et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

et al. 2021

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The purpose of this study was to determine the mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from biopsy samples that were collected from the endoscopic ward of Shahrekord Hajar teaching Hospital and also to study the frequency of virulence factor and their correlation and pathological findings with clarithromycin resistance during the years 2019–2020. In this cross-sectional descriptive study, 152 patients with Helicobacter pylori infection were considered, and then, two common A2142G and A2143G mutations in the 23SrRNA gene associated with resistance were analyzed by Real-time PCR (Taq man). The presence of vacA, iceA1, iceA2, cagA, babA2, and oipA virulence genes was investigated by PCR and electrophoresis in 8% polyacrylamide gel. Then, data were analyzed using the relevant statistical tests. In this study, the frequency of Helicobacter pylori was 76% and the frequency of mutant isolates was 57.2%. The frequencies of A2142G and A2143G point mutations were 42.1% and 28.3%. There was a significant correlation among oipA, vacA, and iceA1 virulence factors, type of disease, chronic inflammatory score, and glandular atrophy with the antibiotic resistance to clarithromycin. There was no significant correlation between the age and sex of the patients with antibiotic resistance. According to the results of this study, it seems that the use of clarithromycin to combat this bacterium should be limited.

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Section: Introductionmentioning

confidence: 99%

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

et al. 2021

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“…H. pylori is a major human pathogen which produces inflammation of the stomach and is etiologically related to chronic gastritis and PUD, but not all H. pylori -positive subjects develop such diseases [ 20 , 21 , 22 ]. Approximately 50 percent of the human population worldwide is chronically infected with H. pylori without any clinical symptoms and there are significant variations in its prevalence between different countries [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

Abadi

Ashrafi-Dehkordi

Ahmadi

et al. 2021

Heliyon

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Helicobacter pylori ( H. pylori ) is a gram-negative which can cause several gastroduodenal diseases, including gastritis and peptic ulcer disease (PUD). H. pylori specific genotypes have been related to increased occurrence of gastritis and PUD. The aim of this study was to investigate the clinical relevance of the major virulence factors of H . pylori with clinical outcomes and histological parameters in Iranian patients. Totally, 200 subjects with PUD and gastritis disease who underwent gastroduodenal endoscopy were enrolled in this study. The presence of the cagA , vacA , oipA , babA2 , and iceA genes in antral gastric biopsy specimens were determined by polymerase chain reaction (PCR) and the results were compared with clinical outcomes and histological parameters. The frequency of babA2 + , oipA + , vacA s1/m2 , and vacA m2 genes was significantly higher in patients with peptic ulcer disease compared with patients with gastritis. In contrast, the frequency of vacA s1/m1 gene was significantly higher in gastritis subjects than PUD subjects. The high-density scores of H. pylori were strongly associated with iceA1 ¯ , babA2 + , and oipA + genes. Additionally, the high polymorphonuclear cell infiltration and high mononuclear cell infiltration scores were strongly associated with the cagA + , iceA1 ¯ , oipA + genes and cagA + , babA2 + , oipA + genes, respectively. Our study indicated that the vacA , babA2 , and oipA virulence factors are related to a higher risk of PUD in subjects with H. pylori -infection. Infection with these strains was associated with a more severe gastropathy.

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“…The presence of primer‐dimer in all primer pairs was investigated by the three‐step protocol. The relative expression of the mRNA level was calculated using the 2 −∆∆Ct method (Sanaei et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Comparing the frequency of CD33⁺ pSTAT3⁺ myeloid‐derived suppressor cells and IL‐17⁺ lymphocytes in patients with prostate cancer and benign prostatic hyperplasia

Sanaei

Taheri

Heshmati

et al. 2021

Cell Biology International

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Prostate cancer (PCa) is one of the most epidemic types of cancer in men. The tumor microenvironment (TME) of PCa is involved in the emergence of immunosuppressive factors such as myeloid‐derived suppressor cells (MDSC), which regulate the immune system by several mechanisms, including interleukin (IL)‐10 production. On the other hand, IL‐17+ helper T cells (Th17) induce MDSCs and chronic inflammation in TME by producing IL‐17. This study demonstrated that the frequency of CD33+ pSTAT3+ MDSC and IL‐17+ lymphocyte as well as IL‐10 messenger RNA (mRNA) expression were significantly higher in the PCa patients than in the benign prostatic hyperplasia (BPH) group. Moreover, there was no significant relationship between the frequency of CD33+ pSTAT3+ MDSC, and IL‐17+ lymphocyte with Gleason scores in the PCa group. We suggested that the higher frequency of CD33+ pSTAT3+ MDSC and IL‐17+ lymphocyte and the more frequent expression of IL‐10 mRNA in PCa patients may play roles in tumor progression from BPH to PCa.

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Up-regulated CCL18, CCL28 and CXCL13 Expression is Associated with the Risk of Gastritis and Peptic Ulcer Disease in Helicobacter Pylori infection

Cited by 12 publications

References 37 publications

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

Comparing the frequency of CD33⁺ pSTAT3⁺ myeloid‐derived suppressor cells and IL‐17⁺ lymphocytes in patients with prostate cancer and benign prostatic hyperplasia

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Up-regulated CCL18, CCL28 and CXCL13 Expression is Associated with the Risk of Gastritis and Peptic Ulcer Disease in Helicobacter Pylori infection

Cited by 12 publications

References 37 publications

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

Comparing the frequency of CD33+ pSTAT3+ myeloid‐derived suppressor cells and IL‐17+ lymphocytes in patients with prostate cancer and benign prostatic hyperplasia

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Product

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Comparing the frequency of CD33⁺ pSTAT3⁺ myeloid‐derived suppressor cells and IL‐17⁺ lymphocytes in patients with prostate cancer and benign prostatic hyperplasia